| Rational approach to treatment options for Lennox-Gastaut syndrome. | |
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MedLine Citation:
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PMID: 21790561 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lennox-Gastaut syndrome (LGS) is an intractable childhood-onset epileptic encephalopathy. Seizure freedom is rare in LGS. One of the hallmarks of LGS is medical intractability, with generally poor response to antiepileptic drugs (AEDs). Nevertheless, several treatment options are available that can mitigate the severity of seizures and curtail their frequency. New AEDs have been validated in randomized, controlled trials for the treatment of seizures in LGS. In some cases, nonpharmacologic options may be effective, although more data are needed to confirm efficacy outcomes. Comprehensive patient assessments are critical to achieve an optimal AED treatment regimen and minimize the potential for adverse effects. |
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Authors:
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Georgia D Montouris |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epilepsia Volume: 52 Suppl 5 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 10-20 Citation Subset: IM |
Copyright Information:
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Wiley Periodicals, Inc. © 2011 International League Against Epilepsy. |
Affiliation:
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Department of Neurology, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts, U.S.A. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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