| Rational exploration of N-heterocyclic carbene (NHC) palladacycle diversity: a highly active and versatile precatalyst for Suzuki-Miyaura coupling reactions of deactivated aryl and alkyl substrates. | |
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MedLine Citation:
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PMID: 20175159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As less attention has been focussed on the design of highly efficient palladium precatalysts to ensure the smooth formation of the active catalyst for metal-mediated cross coupling reactions, we herein demonstrate that combining the bulky N-heterocyclic carbene (NHC) 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr) with cyclopalladated acetanilide as the optimal palladium precatalyst leads to superior catalytic activity compared with the state-of-the-art NHC-Pd catalysts. The complex was discovered through the evaluation of a small, rationally designed library of NHC-palladacycles prepared by a novel, practical and atom-economic method, the direct reaction of IPrHCl with palladacycle acetate dimers. |
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Authors:
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Guang-Rong Peh; Eric Assen B Kantchev; Jun-Cheng Er; Jackie Y Ying |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: 16 ISSN: 1521-3765 ISO Abbreviation: Chemistry Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: Germany |
Other Details:
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Languages: eng Pagination: 4010-7 Citation Subset: IM |
Affiliation:
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Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catalysis Cross-Linking Reagents / chemistry* Crystallography, X-Ray Dimerization Heterocyclic Compounds / chemistry* Imidazoles / chemistry* Methane / analogs & derivatives*, chemistry Models, Molecular Palladium / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene; 0/Cross-Linking Reagents; 0/Heterocyclic Compounds; 0/Imidazoles; 2465-56-7/carbene; 74-82-8/Methane; 7440-05-3/Palladium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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