Document Detail


Ratiometric spectral imaging for fast tumor detection and chemotherapy monitoring in vivo.
MedLine Citation:
PMID:  21721808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a novel in vivo spectral imaging approach to cancer detection and chemotherapy assessment. We describe and characterize a ratiometric spectral imaging and analysis method and evaluate its performance for tumor detection and delineation by quantitatively monitoring the specific accumulation of targeted gallium corrole (HerGa) into HER2-positive (HER2 +) breast tumors. HerGa temporal accumulation in nude mice bearing HER2 + breast tumors was monitored comparatively by a. this new ratiometric imaging and analysis method; b. established (reflectance and fluorescence) spectral imaging; c. more commonly used fluorescence intensity imaging. We also tested the feasibility of HerGa imaging in vivo using the ratiometric spectral imaging method for tumor detection and delineation. Our results show that the new method not only provides better quantitative information than typical spectral imaging, but also better specificity than standard fluorescence intensity imaging, thus allowing enhanced in vivo outlining of tumors and dynamic, quantitative monitoring of targeted chemotherapy agent accumulation into them.
Authors:
Jae Youn Hwang; Zeev Gross; Harry B Gray; Lali K Medina-Kauwe; Daniel L Farkas
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  16     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-11-08     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  066007     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Contrast Media / diagnostic use*,  pharmacokinetics
Drug Monitoring / methods*
Female
Gallium / diagnostic use,  pharmacokinetics
Mice
Mice, Nude
Molecular Imaging / methods*
Neoplasms / drug therapy,  enzymology,  metabolism,  pathology*
Receptor, erbB-2 / biosynthesis
Spectrometry, Fluorescence
Transplantation, Heterologous
Grant Support
ID/Acronym/Agency:
DK019038/DK/NIDDK NIH HHS; R01 CA129822/CA/NCI NIH HHS; R01 CA129822/CA/NCI NIH HHS; R01 CA140995/CA/NCI NIH HHS; R01 CA140995/CA/NCI NIH HHS; R01 DK019038/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; CH46OC8YV4/Gallium; EC 2.7.10.1/Erbb2 protein, mouse; EC 2.7.10.1/Receptor, erbB-2
Comments/Corrections

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