| Ratio of lung to heart thallium-201 uptake on exercise and dipyridamole stress imaging in coronary artery disease--implication of SPECT. | |
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MedLine Citation:
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PMID: 8510308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine whether measurements of lung thallium-201 (Tl-201) uptake with single photon emission computed tomography (SPECT) following exercise or dipyridamole infusion provide complementary information as reported in planar imaging, we examined 140 patients undergoing exercise or dipyridamole Tl-201 SPECT and coronary arteriography for the diagnosis of coronary artery disease (CAD). On the reconstructed coronal tomographic image, regions of interest were placed over the left upper lung field and the left ventricular myocardium. Lung to heart ratio (L/H ratio) was calculated as a fraction of average Tl-201 counts per pixel in the lung divided by those in the myocardium. An L/H ratio of larger than a value of mean +2 standard deviation, derived from patients without significant coronary stenosis, was considered as abnormal. The patients with abnormal L/H ratio on exercise Tl-201 SPECT had larger extent and severity scores of Tl-201 defects on the initial image, lower left ventricular ejection fraction, higher end-diastolic pressure and higher incidence of multi-vessel CAD than those with the normal ratio. However, in dipyridamole studies, abnormal L/H ratio did not relate to scintigraphic or hemodynamic severity. These data confirmed that increased lung Tl-201 uptake after exercise suggested the presence of extensive CAD or left ventricular dysfunction. However, L/H ratio might be less useful in dipyridamole studies. Thus, quantitative measurements of L/H ratio with exercise but not dipyridamole SPECT could provide additional information related to the involved cardiac pump performance in CAD. |
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Authors:
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Y Takeishi; J Chiba; S Abe; H Tomoike |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese circulation journal Volume: 57 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-07-12 Completed Date: 1993-07-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 379-87 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Yamagata University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Coronary Disease / metabolism, radionuclide imaging* Dipyridamole / diagnostic use, pharmacokinetics* Exercise Test Female Heart / physiology, radionuclide imaging* Hemodynamics / physiology Humans Lung / metabolism, radionuclide imaging* Male Middle Aged Myocardium / metabolism Thallium Radioisotopes / diagnostic use* Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Thallium Radioisotopes; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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