Document Detail

Leptin/adiponectin ratio is an independent predictor of mortality in nondiabetic peritoneal dialysis patients.
MedLine Citation:
PMID:  22855891     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The leptin/adiponectin (L/A) ratio has been suggested to be an atherosclerotic index for diabetic patients and a useful marker of insulin resistance in patients with and without diabetes. Even though end-stage renal disease (ESRD) patients on peritoneal dialysis (PD) are well characterized by abnormal adipocytokine metabolism, the significance of alterations in the L/A ratio is largely unexplored in these patients. In this prospective study, we investigated the associations of leptin, adiponectin, and the L/A ratio with clinical outcomes in nondiabetic PD patients.
METHODS: The study included 131 stable nondiabetic ESRD patients who had been on PD for more than 3 months. Serum leptin and adiponectin levels were determined at baseline. Mortality was evaluated over a 5-year follow-up period.
RESULTS: During the follow-up period, 22 patients died (16.8%), including 10 (45.5%) as a result of cardiovascular disease. The L/A ratio showed a significant positive correlation with body mass index [BMI (r = 0.47, p < 0.001)], high-sensitivity C-reactive protein (r = 0.32, p < 0.001), and triglycerides (r = 0.43, p < 0.001). In addition, we observed significant inverse correlations between the L/A ratio and percentage lean body mass (r = -0.30, p = 0.001) and high-density lipoprotein cholesterol (r = -0.31, p = 0.001). In contrast to individual leptin and adiponectin levels, the L/A ratio was found to be independently associated with an increased mortality risk (relative risk: 1.15; 95% confidence interval: 1.05 to 1.27; p = 0.003) even after adjustments for age and BMI.
CONCLUSIONS: The L/A ratio might be better related to patient outcomes than adipocytokines are individually in nondiabetic patients undergoing PD.
Jung Tak Park; Tae-Hyun Yoo; Jwa-Kyung Kim; Hyung Jung Oh; Seung Jun Kim; Dong Eun Yoo; Mi Jung Lee; Dong Ho Shin; Seung Hyeok Han; Dae-Suk Han; Shin-Wook Kang
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-01
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  33     ISSN:  1718-4304     ISO Abbreviation:  Perit Dial Int     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-07-16     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  67-74     Citation Subset:  IM    
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MeSH Terms
Adiponectin / blood*
Atherosclerosis / blood*,  complications,  mortality
Biological Markers / blood
Diabetes Mellitus
Follow-Up Studies
Kidney Failure, Chronic / blood,  complications,  therapy*
Leptin / blood*
Middle Aged
Peritoneal Dialysis / mortality*
Prospective Studies
Republic of Korea / epidemiology
Survival Rate / trends
Time Factors
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Leptin

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