Document Detail

Ratio between aldosterone and atrial natriuretic peptide in pregnancy.
MedLine Citation:
PMID:  2533297     Owner:  NLM     Status:  MEDLINE    
The possibility of evaluating the ratio between aldosterone and atrial natriuretic peptide (ANP) instead of the two hormones by themselves in studying sodium handling in normal pregnancy and in preeclampsia in the steady state and following albumin infusion was examined in this study. In 32 normal pregnancies monitored monthly, the highest aldosterone/ANP ratio was observed in the last weeks (28.7 +/- 12), and dropped in the first postpartum week (3.6 +/- 2.8), without changes in fractional excretion of sodium. In 18 preeclamptic patients, the ratio was significantly lower than in normal pregnancy at the same gestational ages, and it was coupled with absolute reduction in the sodium excretion. Among preeclamptic patients, a significant inverse correlation (P less than 0.025) was revealed between the ratio and sodium excretion. Natriuresis in response to acute volume expansion with albumin infusion occurred only in 50% of preeclamptic patients, and was associated with an ANP increase, an aldosterone decrease, and a further decrease in the ratio. A blunted natriuresis was observed in cases with a particularly low prealbumin value of this ratio. Furthermore, in preeclampsia, a particularly low ratio seemed to be typical of the patients who showed poorer placental flows and fetal outcomes. These results suggest that the balance between aldosterone and ANP may be a useful index in understanding sodium homeostasis in these settings.
P Stratta; C Canavese; L Gurioli; M Porcu; T Todros; G C Mattone; O Fianchino; L Gagliardi; A Vercellone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  36     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-03-05     Completed Date:  1990-03-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  908-14     Citation Subset:  IM    
Department of Nephrology and Clinical Obstetrics, University of Torino, Italy.
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MeSH Terms
Aldosterone / blood*
Atrial Natriuretic Factor / blood*
Natriuresis / physiology*
Pre-Eclampsia / blood*
Pregnancy / blood*
Water-Electrolyte Balance / physiology
Reg. No./Substance:
52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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