Document Detail


The ApoB/A-I Ratio and Metabolic Syndrome in Prepubertal Children.
MedLine Citation:
PMID:  23336584     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Studies about the relationship of apolipoproteins (apo) and metabolic syndrome in children are scarce. In this study, we analyze apo levels and determine the best cutoff point of the apoB/A-I ratio to diagnose dyslipidemia in prepubertal children with metabolic syndrome. Methods: A community-based, cross-sectional study that enrolled 337 children with Tanner stage 1 and average age and body mass index of 9.7±1.6 years and 19.2±3.8 kg/m(2) was carried out. Diagnosis of acute or chronic illnesses constituted the exclusion criteria; in addition, children undergoing medical treatment or receiving vitamins and/or oral supplements were not included. Results: Metabolic syndrome was identified in 42 (12.5%) children (19 girls and 23 boys). The mean apoB/A-I ratio in the children with metabolic syndrome was 0.67±0.18. The best cutoff point of the apoB/A-I ratio for recognizing dyslipidemia was 0.60 (area under the receiver operating characteristic curve, 0.778; sensitivity 80%, specificity 55%). A total of 102 children exhibited apoB/A-I ratio ≥0.60. Diagnosis of metabolic syndrome was performed in 42 (41.2%) children. Among children with metabolic syndrome, 38 (90.5%) had hypertriglyceridemia, 34 (81.0%) low high-density lipoprotein cholesterol (HDL-C), 32 (76.2%) hypertriglyceridemia+low HDL-C, and 40 (95.2%) an apoB/A-I ratio ≥0.60. Conclusion: Our results show that the best cutoff point of the apoB/A-I ratio for recognizing dyslipidemia in prepubertal children is 0.60 and that among children with metabolic syndrome, an apoB/A-I ratio ≥0.60 is the marker of dyslipidemia with the highest frequency.
Authors:
Martha Rodríguez-Moran; Celia Aradillas-García; Fernando Guerrero-Romero
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Metabolic syndrome and related disorders     Volume:  -     ISSN:  1557-8518     ISO Abbreviation:  Metab Syndr Relat Disord     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150318     Medline TA:  Metab Syndr Relat Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Biomedical Research Unit, Mexican Social Security Institute , Durango, Mexico .
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