Document Detail


Rates of twinning before and after fortification of foods in the US with folic acid, Texas, 1996 to 1998.
MedLine Citation:
PMID:  14629320     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several investigators have reported a 40% increase in the prevalence of twinning among women who have taken folic acid or multivitamins containing folic acid at the time of conception. Given that infant morbidity and mortality are greatly increased among twins, such a large increase in twinning could have serious implications. We undertook this study to determine if US fortification of enriched cereal-grain products with folic acid was associated with an unexpected increase in the prevalence of twinning in the state of Texas. We examined 1 003 207 deliveries conceived in Texas, between 1 January 1996 and 31 December 1998. We compared the prevalence of twin deliveries conceived before, during and after fortification with folic acid, mandated to begin on 1 January 1998. Comparing pregnancies conceived in 1997 with those conceived in 1996, we observed a 2.4% yearly increase in twinning, 1.024 [0.98, 1.07]. Comparing pregnancies conceived in 1998 with those conceived in 1997, we observed a 4.6% yearly increase in twinning, 1.046 [1.00, 1.09]. These increases were adjusted for maternal age, race, education, parity and season of conception. The size and pattern of these increases are consistent with the ongoing increase in twinning of 1-4% per year which began in the US prior to fortification.
Authors:
D K Waller; A T N Tita; J F Annegers
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  17     ISSN:  0269-5022     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-02-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  378-83     Citation Subset:  IM    
Affiliation:
The University of Texas Houston Health Science Center, School of Public Health, Houston, TX 77030, USA. kwaller@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Dietary Supplements*
Female
Folic Acid / administration & dosage*
Food, Fortified*
Humans
Multivariate Analysis
Neural Tube Defects / prevention & control
Preconception Care / methods*
Pregnancy
Pregnancy, Multiple* / statistics & numerical data
Prevalence
Seasons
Texas / epidemiology
Twins, Dizygotic / statistics & numerical data
Twins, Monozygotic / statistics & numerical data
Chemical
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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