| Rates of polypeptide chain assembly in liver in vivo: relation to the mechanism of temperature acclimation in Opsanus tau. | |
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MedLine Citation:
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PMID: 5253648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simple translational model, present herein, permits experimental determination of the rates of protein synthesis in vivo in terms of a time constant representing the average assembly time of the polypeptide chains. The model has been used to interpret incorporation of radioactive amino acids into toadfish liver fractions as a function of time after hepatic portal vein injection. The results suggest that the increase in liver protein synthesis produced by cold acclimation is due to a more rapid rate of addition of amino acid residues to the growing polypeptide chains. The finding is consistent with the greater aminoacyl transferase activity in livers of cold-acclimated fish. |
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Authors:
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A E Haschemeyer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 62 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1969 Jan |
Date Detail:
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Created Date: 1969-06-29 Completed Date: 1969-06-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 128-35 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization* Animals Fishes / metabolism* Liver / enzymology*, physiology* Mathematics Models, Biological Peptide Biosynthesis* Protein Biosynthesis* Time Transaminases / metabolism* |
| Chemical | |
Reg. No./Substance:
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EC 2.6.1.-/Transaminases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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