Document Detail

Rates of local cerebral protein synthesis in fetal and neonatal sheep.
MedLine Citation:
PMID:  9140025     Owner:  NLM     Status:  MEDLINE    
During gestation there is likely to be a constantly changing rate of protein synthesis in the brain that may exhibit regional specificity. With the use of the quantitative autoradiographic L-[1-(14)C]leucine method for the determination of local rates of leucine incorporation into cerebral protein (lCPS(Leu)), we have sought to characterize this important process. lCPS(Leu) was measured in nine fetal sheep (118-139 days gestational age) and five newborn lambs (1-5 days of age). In other experiments, the fraction of leucine in the precursor pool for protein synthesis in the brain derived from the arterial plasma was determined to be 0.57 +/- 0.04 (mean +/- SE) in one fetus and two lambs. This value was used in the calculation of lCPS(Leu) in 35 regions of the central nervous system, pineal body, and whole brain. Regardless of age, lCPS(Leu) was highest in the pineal body, brain stem, and hypothalamic nuclei and lowest in white matter. In sensorimotor cortex, corona radiata, pyramidal tracts, and whole brain, lCPS(Leu) was positively correlated with prenatal age (P < or = 0.05). These increases in lCPS(Leu) probably reflect myelination in the cerebrum, which is known to occur in late gestation.
R M Abrams; D J Burchfield; Y Sun; C B Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-28     Completed Date:  1997-05-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1235-44     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Florida Medical Center, Gainesville 32610, USA.
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MeSH Terms
Aging / metabolism*
Animals, Newborn
Brain / embryology,  growth & development,  metabolism*
Carbon Radioisotopes
Embryonic and Fetal Development
Gestational Age
Leucine / metabolism
Nerve Tissue Proteins / biosynthesis*
Organ Specificity
Regression Analysis
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Nerve Tissue Proteins; 61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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