Document Detail

Rate of serious adverse effects in a series of bevacizumab and ranibizumab injections.
MedLine Citation:
PMID:  22687306     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the rate of serious ocular and systemic adverse effects of intravitreal bevacizumab and ranibizumab in the treatment of a variety of eye diseases.
DESIGN: Retrospective chart review.
PARTICIPANTS: Consecutive series of intravitreal injections of bevacizumab (n = 693) and ranibizumab (n = 891).
METHODS: Medical records of all patients receiving injections in the series were retrieved. We considered the rate of both serious ocular adverse effects (e.g., acute intraocular inflammation, infectious endophthalmitis, retinal detachment, vitreous hemorrhage) and of arterial thromboembolic events that occurred within 1 month of injection.
RESULTS: Subjects who received bevacizumab were 12 times more likely to develop severe intraocular inflammation following each injection than were those who received ranibizumab (OR = 11.71; 95% CI 1.5-93). The 1 case of acute intraocular inflammation following ranibizumab injection was mild and not associated with vision loss. No other serious ocular complications were noted. A trend was also noted toward an increased risk for arterial thromboembolic events in patients receiving bevacizumab, although the confidence interval was wide (OR = 4.26; 95% CI 0.44-41).
CONCLUSIONS: Significant concern still exists regarding the safety of off-label use of intravitreal bevacizumab. Patients receiving bevacizumab should be counselled regarding a possible increased risk for serious adverse events.
Sanjay Sharma; Davin Johnson; Marwan Abouammoh; Simon Hollands; Ashley Brissette
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie     Volume:  47     ISSN:  0008-4182     ISO Abbreviation:  Can. J. Ophthalmol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-08-16     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0045312     Medline TA:  Can J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
Department of Ophthalmology, Queen's University, Kingston, Ont.
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MeSH Terms
Aged, 80 and over
Angiogenesis Inhibitors / adverse effects*
Antibodies, Monoclonal, Humanized / adverse effects*
Endophthalmitis / epidemiology*,  etiology
Intravitreal Injections
Macular Edema / drug therapy
Middle Aged
Retinal Detachment / epidemiology*,  etiology
Retinal Vein Occlusion / drug therapy
Retrospective Studies
Risk Factors
Thromboembolism / epidemiology*,  etiology
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Visual Acuity
Vitreous Hemorrhage / epidemiology*,  etiology
Wet Macular Degeneration / drug therapy
Grant Support
200101MSH-87845-60447//Canadian Institutes of Health Research
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 0/ranibizumab; 2S9ZZM9Q9V/bevacizumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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