| Rate and predictors of optimal virologic response to antiretroviral therapy in Colombia. | |
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MedLine Citation:
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PMID: 17512234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the rate of optimal response to antiretroviral therapy and its predictors in Colombia. METHODS: A retrospective cohort study was performed. The medical records of all patients at three major HIV clinics in different areas of Colombia, South America, were reviewed. Eligible patients met the following criteria: (1) viral load test available while on therapy; and (2) patients must have been on a stable first antiviral regimen for at least 1 year (48 weeks). Optimal virologic response was defined as a viral load <400 copies/ml. RESULTS: Two hundred and twenty patients were eligible for the study. The optimal virologic response rate was 40% (95% confidence interval 34-46%). Younger age (p=0.02) and western region of the country (p=0.026) were the only significant predictors of non-optimal response in bivariate analysis. Multivariate logistic regression analysis confirmed younger age (p=0.0054) and geographic area (p=0.0468) as independent predictors of non-optimal response. CONCLUSIONS: The optimal response rate in some areas of Colombia seems lower than that reported for other areas of the developing world. Poorer virologic responses were observed in younger patients and in those from the western region of the country. |
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Authors:
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Carlos A Diazgranados; Alfonso Silva; Adriana Bermudez; Diana Roncancio; Pierina Diruggiero; Monica Mantilla |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-23 |
Journal Detail:
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Title: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Volume: 11 ISSN: 1201-9712 ISO Abbreviation: Int. J. Infect. Dis. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-30 Completed Date: 2008-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610933 Medline TA: Int J Infect Dis Country: Canada |
Other Details:
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Languages: eng Pagination: 531-5 Citation Subset: IM |
Affiliation:
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Fundación Universitaria de Ciencias de Salud, Bogotá, Colombia. cdiazgr@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Retroviral Agents / therapeutic use* Child Child, Preschool Cohort Studies Colombia Female HIV Infections / drug therapy*, virology Humans Logistic Models Male Middle Aged Multivariate Analysis Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anti-Retroviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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