Document Detail


Rate of occult specimen provenance complications in routine clinical practice.
MedLine Citation:
PMID:  23270904     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Occult specimen provenance complications (SPCs), which occur when there is an absence of any direct or indirect indication that a specimen switch or contamination may have occurred, constitute a significant patient safety and medical-legal problem because they can lead to misdiagnosis. However, the rate at which occult SPCs occur is unknown because, by definition, this category of errors is not identified by standard laboratory practices. In this study, we evaluated a data set comprising almost 13,000 prostate biopsies that were prospectively tested for specimen provenance errors as part of routine clinical practice. The frequency of occult type 1 errors (a complete transposition between patients) and type 2 errors (contamination of the patient's tissue with 1 or more unrelated patients) was 0.26% and 0.67%, respectively; every urology practice setting and surgical pathology laboratory type with a representative sample size experienced at least 1 type 1 and 1 type 2 error during the study period. Overall, the mean frequency of SPCs across practice settings was 0.22% for type 1 errors and 1.69% for type 2 errors. The type 1 rate showed no correlation with a surgical pathology laboratory setting or urologic practice group setting; the type 2 rate correlated solely with a surgical pathology laboratory setting. The occult SPC rate in this limited data set provides an estimate of the scope of the problem of potential misdiagnosis as a result of occult specimen provenance errors in routine clinical practice.
Authors:
John D Pfeifer; Jingxia Liu; Phd
Related Documents :
16442684 - Revised assessment of cancer risk to dichloromethane: part i bayesian pbpk and dose-res...
21849314 - Parallel evolutionary trajectories underlie the origin of giant suspension-feeding whal...
15196814 - Hiv hollow fiber scid model for antiviral therapy comparison with scid/hu model.
21669634 - Myrtaceae revisited: a reassessment of infrafamilial groups.
23412994 - Phylogeny, biogeography and divergence times in passiflora (passifloraceae).
17717554 - Body, mind and bonds.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  139     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  AIM; IM    
Affiliation:
Dept of Pathology, Washington University School of Medicine, Campus Box 8118, 660 S Euclid Ave, St Louis, MO 63110.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The role of s100-positive dendritic cells in the prognosis of papillary thyroid carcinoma.
Next Document:  The effect of dabigatran on select specialty coagulation assays.