| Rate of generation of myocardial power density normalized by cardiac frequency. | |
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MedLine Citation:
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PMID: 474795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We introduce a frequency normalized, power averaged, rate of generation of power density (FARPD) that extends the range of applicability of the averaged rate of generation of power density (ARPD) to any cardiac frequency encountered in experimental or clinical situations. Normalization eliminates the frequency-dependent mathematical artifacts arising during the computation of quantities containing time derivatives of the pressure, while preserving the effects of changes in heart rate on the cardiac muscle itself (Bowditch type of phenomena). The distribution of normal values in a group of 51 control dogs was very close to the standard normal distribution. These values had no statistically significant differences with those of a smaller control group studied by independent investigators. Isoproterenol and propranolol produced highly significant statistical changes in FARPD. Alterations in pre- and afterload produced changes that were not significant for the former and significant at the 5% level for the latter. These changes were small when compared to those resulting from typical inotropic interventions. |
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Authors:
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A H Moreno; M E Bloomfield; E A Grossi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 237 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1979 Sep |
Date Detail:
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Created Date: 1979-10-26 Completed Date: 1979-10-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R225-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Heart / physiology* Heart Rate / drug effects* Isoproterenol / pharmacology Mathematics Myocardial Contraction / drug effects* Propranolol / pharmacology Reference Values Thermodynamics |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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