Document Detail

Rate of formation of norpethidine from pethidine.
MedLine Citation:
PMID:  7470361     Owner:  NLM     Status:  MEDLINE    
The concentrations of norpethidine in blood were determined in patients recovering from abdominal surgery following both multiple i.m. injections (i.m. group) and the i.v. infusion (i.v. group) of pethidine. The rate of administration of pethidine averaged 25 mg h-1 in both groups. Concentrations of norpethidine were generally small compared with those of pethidine although the ratio of norpethidine to pethidine concentrations increased steadily over the 2 days studied. The rate of increase of blood concentration of norpethidine was 0.013 micrograms ml-1 h-1 in both groups of patients. No significant toxic effects were observed.
K L Austin; J V Stapleton; L E Mather
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  53     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  255-8     Citation Subset:  IM    
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MeSH Terms
Infusions, Parenteral
Injections, Intramuscular
Meperidine / administration & dosage,  analogs & derivatives*,  blood
Reg. No./Substance:
57-42-1/Meperidine; 77-17-8/normeperidine

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