Document Detail

Rate of endometrial adenocarcinoma in women screened before and after implementation of the Bethesda 2001 reporting system.
MedLine Citation:
PMID:  18323269     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the impact of the recommendation of the 2001 Bethesda System to report all benign-appearing endometrial cells seen in women aged > or = 40 years on the frequency with which endometrial carcinomas are potentially detected as a consequence of Pap test reports that mention endometrial cells. STUDY DESIGN: We identified all women diagnosed with endometrial adenocarcinoma who also had a Pap test during the preceding 6 months. The search was performed for 3-year periods before and after the date of implementation of Bethesda 2001. RESULTS: Benign endometrial cells were reported for 589 women in the 3 years before Bethesda 2001 and for 3,810 women in the 3 following years. The number of endometrial malignancies found on follow-up in these women decreased from 8 in the 3 years before Bethesda 2001 to only 4 subsequently. The frequency of reporting atypical or malignant glandular cells, as well as the likelihood of finding endometrial malignancy on follow-up, did not significantly change. CONCLUSION: Despite a 6.5-fold rise in the frequency of reporting benign endometrial cells after Bethesda 2001, the frequency of subsequent diagnosis of endometrial malignancies did not in-crease.
Michael Thrall; Klint Kjeldahl; Kay Savik; H Evin Gulbahce; Stefan E Pambuccian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  52     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-03-07     Completed Date:  2008-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Laboratory Medicine, School of Nursing, University of Minnesota, Minneapolisa 55455, USA.
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MeSH Terms
Adenocarcinoma / diagnosis,  epidemiology*,  pathology
Endometrial Neoplasms / diagnosis,  epidemiology*,  pathology
Vaginal Smears

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