| Rate of delivery of hyperbaric oxygen treatments does not affect response in soft tissue radionecrosis. | |
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MedLine Citation:
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PMID: 18019083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Soft tissue radiation necrosis (STRN) is effectively treated with hyperbaric oxygen (HBO,), believed to result from stimulation ofangiogenesis in radiation-injured tissue. Thirty to forty HBO2 treatments are usually recommended for STRN. For various reasons, different hyperbaric facilities offer these treatments once or twice daily and from 5-7 days weekly. It is not known whether the clinical response differs as a result of the rate of administration of HBO2 treatments. METHODS: Details of hyperbaric treatment courses of patients treated for radiation enteritis/proctitis (n = 65) and cystitis (n = 94) at a single institution were reviewed. Outcomes were compared with the total number of HBO2 treatments administered and also rate of treatment administration. RESULTS: Responses were similar for both forms of STRN whether the patient averaged fewer or greater than 5 treatments per week, or even < or = 3 versus > or = 7 treatments weekly. Outcome did differ, however, dependant on the total number of treatments administered. Response was better in patients receiving 30 or more total treatments, as compared with fewer. CONCLUSIONS: Soft tissue radionecrosis of the gastrointestinal tract or bladder is (1) effectively treated with hyperbaric oxygen, (2) has a higher response rate if at least 30 treatments are administered, and (3) is equally responsive to rates of hyperbaric treatment ranging from 3 or fewer to 7 or more treatments per week. |
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Authors:
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N B Hampson; J M Corman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc Volume: 34 ISSN: 1066-2936 ISO Abbreviation: Undersea Hyperb Med Publication Date: 2007 Sep-Oct |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2007-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312954 Medline TA: Undersea Hyperb Med Country: United States |
Other Details:
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Languages: eng Pagination: 329-34 Citation Subset: IM; S |
Affiliation:
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Center for Hyperbaric Medicine, Section of Pulmonary and Critical Care Medicine, Virginia Mason Medical Center Seattle, Washington, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Cystitis / therapy* Enteritis / therapy* Humans Hyperbaric Oxygenation / methods, utilization* Middle Aged Proctitis / therapy* Radiation Injuries / therapy* Retrospective Studies Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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