| Rate-Controlling Isomerizations in Fatty Acid Oxidations by a Cytochrome P450 Compound I. | |
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MedLine Citation:
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PMID: 22298496 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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KIE events: Hydroxylations of fatty acids by cytochrome P450 119 Compound I display no intermolecular kinetic isotope effect (KIE) in buffer and increase in rate with increasing chain length. With glycerol, the rate of reaction of lauric acid increases, and the KIE is revealed. The mechanism involves reversible formation of an unreactive complex of fatty acid with Compound I and its isomerization to a reactive one. |
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Authors:
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Zhi Su; Xiaohong Chen; John H Horner; Martin Newcomb |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-1 |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: - ISSN: 1521-3765 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St., Chicago, IL 60607 (USA), Fax: (+1) 312-996-3161. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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