| Rat small intestinal goblet cell kinetics in the process of restitution of surface epithelium subjected to ischemia-reperfusion injury. | |
| | |
MedLine Citation:
|
PMID: 11911348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Repair of superficial damage to gastrointestinal mucosa occurs by a process called restitution. Goblet cells reside throughout the length of the intestine and are responsible for the production of mucus. However, a kinetic analysis of goblet cell dynamics of small intestine in restitution has hitherto not been reported. The aim of the present study was to investigate the role of goblet cells in the process of restitution of rat small intestine subjected to ischemia and ischemia-reperfusion injury, and therefore intestinal epithelium from rats subjected to both ischemia and ischemia-reperfusion was studied. Detachment of enterocytes was observed after 5-min of reperfusion. After 20-30 minutes of reperfusion, the denuded villous tips were covered with goblet cells. Within 75 min of reperfusion the epithelium restitution was complete. On the other hand, restitution was not observed in ischemia group. These data suggest that goblet cells may play an important role in restitution after ischemia-reperfusion injury. |
| | |
Authors:
|
Hiroshi Ikeda; Chao-Long Yang; Jie Tong; Haruaki Nishimaki; Kenji Masuda; Tomohiro Takeo; Kenji Kasai; Gen Itoh |
Related Documents
:
|
6650438 - Light and electron microscopic cytochemistry of glycoconjugates in the rectosigmoid col... 2688578 - Endpolyploidy and digestion in the midgut of rhodnius prolixus stål (hemiptera: reduvi... 930588 - Morphological study of the paneth cell. paneth cells in intestinal metaplasia of the st... 7810658 - Regional differences in glycoconjugates of intestinal m cells in mice: potential target... 8774748 - Induction of vanadium accumulation and nuclear sequestration causing cell suicide in hu... 13878428 - Cytological observations on the chromatin bodies of two bacillus species. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: 47 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-03-25 Completed Date: 2002-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 590-601 Citation Subset: AIM; IM |
Affiliation:
|
First Department of Pathology, Aichi Medical University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals DNA / biosynthesis Enterocytes / pathology, ultrastructure Female Goblet Cells / metabolism, pathology*, physiology, ultrastructure Immunohistochemistry Intestinal Mucosa / pathology*, physiopathology Intestine, Small / metabolism, pathology*, physiopathology Microscopy, Electron Microscopy, Electron, Scanning Permeability Rats Rats, Wistar Reperfusion Injury / metabolism, pathology*, physiopathology |
| Chemical | |
Reg. No./Substance:
|
9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spontaneous gas-forming liver abscess caused by Salmonella within hepatocellular carcinoma: a case r...
Next Document: Reactive oxygen species and vascular cell adhesion molecule-1 in distant organ failure following bil...