Document Detail

Rat models for glaucoma research.
MedLine Citation:
PMID:  18929117     Owner:  NLM     Status:  MEDLINE    
Rats are becoming an increasingly popular model system for understanding mechanisms of optic nerve injury in primary open-angle glaucoma (POAG). Although the anatomy of the rat optic nerve head (ONH) is different from the human, the ultrastructural relationships between astrocytes and axons are quite similar, making it likely that cellular processes of axonal damage in these models will be relevant to human glaucoma. All of these models rely on elevating intraocular pressure (IOP), a major risk factor for glaucoma. Methods that produce increased resistance to aqueous humor outflow at the anterior chamber angle, specifically hypertonic saline injection of aqueous outflow pathways and laser treatment of the limbal tissues, appear to produce a specific regional pattern of injury that may have a particular relevance to understanding regional injury in human glaucoma. Because increased pressure fluctuations are a characteristic of such models and the rodent ONH appears to have high susceptibility to elevated IOP, special instrumentation and measurement techniques are required to document pressure exposure in these eyes and understand the pressure levels that the eyes and the optic nerve are exposed to. With these techniques, it is possible to obtain an excellent correlation between pressure and the extent of nerve damage. Continued use of these models will lead to a better understanding of cellular mechanisms of pressure-induced optic nerve damage and POAG.
John C Morrison; Elaine Johnson; William O Cepurna
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in brain research     Volume:  173     ISSN:  1875-7855     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-03-05     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  285-301     Citation Subset:  IM    
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MeSH Terms
Disease Models, Animal*
Glaucoma, Open-Angle* / pathology,  physiopathology
Intraocular Pressure*
Optic Disk / pathology,  ultrastructure
Tonometry, Ocular / methods
Grant Support
EY010145/EY/NEI NIH HHS; EY016866/EY/NEI NIH HHS; R01 EY010145/EY/NEI NIH HHS; R01 EY010145-11/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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