| Rat model for evaluation of therapeutics on peripheral vascular resistance. | |
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MedLine Citation:
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PMID: 22294176 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Described in this protocol is a rat preparation that serves as a sensitive, reliable in vivo assay of peripheral vascular resistance. Experiments are conducted on conscious animals 5 days following the surgical implantation of an arterial pressure catheter in the carotid artery and a transit time flow probe on the abdominal aorta. The transit time flow probe measures volume blood flow per unit time, making it possible to calculate a true vascular resistance, a reliable indicator of microvascular tone. After allowing appropriate recovery time between experiments, it is possible to use the animal preparation multiple times. This increases study efficiency by reducing the number of animals required and makes it possible to use paired statistical analysis since multiple treatment interventions, including control conditions, can be evaluated in each animal. |
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Authors:
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Roseanne S Wexler; James L Ellis; Gregory P Dubé |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] Volume: Chapter 5 ISSN: 1934-8290 ISO Abbreviation: Curr Protoc Pharmacol Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717249 Medline TA: Curr Protoc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: Unit5.44 Citation Subset: IM |
Affiliation:
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Surface Logix, Inc., Brighton, Massachusetts. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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