Document Detail

Rat gastric acid secretion studies with histamine and synthetic gastrin-like pentapeptide.
MedLine Citation:
PMID:  5545178     Owner:  NLM     Status:  MEDLINE    
1. Gastric acid secretion was measured in the urethane anaesthetized rat whilst maintaining a recirculated gastric perfusion fluid at pH 4.2. The latent period of onset of secretion following single intravenous doses of histamine and pentapeptide in combination was significantly shorter than that following either stimulant alone.3. When administered over a period of 2 hr the maximal steady rate of secretion in response to pentapeptide was 75% of that to histamine.4. Acid stimulatory effects were additive both when the drugs were given concurrently over a 2 hr period and when one was administered after a maximal response had been obtained to the other.5. Although there is some evidence to indicate that histamine and pentapeptide might be initiating acid secretion by different mechanisms it is suggested that they may not be acting with total independence.
R M James
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  212     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1971 Jan 
Date Detail:
Created Date:  1971-04-06     Completed Date:  1971-04-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-93     Citation Subset:  IM    
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