Document Detail

Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture.
MedLine Citation:
PMID:  12124225     Owner:  NLM     Status:  MEDLINE    
The best animal angioplasty model is the porcine model, which is expensive and not available in all laboratories. The aim of this study was to describe a new rat model of angioplasty. An injury was induced with the use of a standard percutaneous transluminal coronary angioplasty (PTCA) 1.5-mm balloon catheter. The neointimal tissue, arterial dimensions, and the injury index were assessed following angioplasty. Ki-67 expression was detected to evaluate cell turnover after balloon angioplasty. In contrast with the standard Clowes model, a significant neointimal formation was detected only in the presence of ruptured internal elastic lamina (IEL). A positive correlation between the percentage of ruptured IEL and the amount of neointimal tissue was also demonstrated. The percentage of IEL fracture correlates with the proliferation index by anti-Ki-67 immunolabeling 7 and 14 days after the angioplasty. Significant arterial negative remodeling was observed following PTCA balloon dilation. In conclusion, our inexpensive animal model of restenosis after angioplasty may have great relevance toward a better understanding of the mechanisms and toward assessment of new therapeutical strategies for this phenomenon.
Ciro Indolfi; Daniele Torella; Carmela Coppola; Eugenio Stabile; Giovanni Esposito; Antonio Curcio; Alfonso Pisani; Luigi Cavuto; Oreste Arcucci; Manuela Cireddu; Giancarlo Troncone; Massimo Chiariello
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  283     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-18     Completed Date:  2002-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H760-7     Citation Subset:  IM    
Division of Cardiology, Magna Graecia University, Via Tommaso Campanella 115, 88100 Catanzaro, Italy.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary / instrumentation
Balloon Dilatation*
Carotid Arteries / pathology,  physiopathology*
Cell Division
Cell Survival
Endothelium, Vascular / pathology,  physiopathology
Rats, Wistar
Rupture / pathology,  physiopathology
Tunica Intima / injuries*,  pathology,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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