Document Detail


Rat behavioral thermoregulation integrates with nonshivering thermogenesis during postnatal development.
MedLine Citation:
PMID:  18085886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rat pups are capable of behavioral thermoregulation, both in the nest and on a thermocline, as early as the 1st week of postnatal life, and these pups can also produce heat metabolically without shivering. The rat pup's primary source of nonshivering thermogenesis is the sympathetically mediated metabolism of brown adipose tissue (BAT). BAT is well formed in newborns and functions shortly after birth. While infant behavioral thermoregulation and BAT thermogenesis have been extensively studied, little is known about the extent to which thermoregulatory behavior can be influenced by BAT thermogenesis. In the present study, 2-, 7-, and 14-day-old pups were observed on a thermal gradient following pharmacological stimulation or inhibition of BAT thermogenesis, and their thermal preferences were quantified. The authors found that 7- and 14-day-old pups treated with norepinephrine (NE), which increases BAT thermogenesis, preferred cooler portions of the gradient than saline-treated controls, whereas 2-day-olds failed to show a similar NE-induced behavioral adjustment. These findings indicate that the ability to adjust thermoregulatory behavior to compensate for enhanced metabolic thermogenesis develops during the 1st week of postnatal life.
Authors:
William J Farrell; Jeffrey R Alberts
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  121     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1333-41     Citation Subset:  IM    
Affiliation:
Department of Psychology, Queens College, City University of New York, Flushing, NY 113667, USA. william.farrel@qc.cuny.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue, Brown / drug effects,  physiology
Age Factors
Analysis of Variance
Animals
Animals, Newborn
Behavior, Animal / drug effects,  physiology*
Body Temperature / drug effects,  physiology*
Body Temperature Regulation / drug effects,  physiology*
Dose-Response Relationship, Drug
Norepinephrine / pharmacology
Rats
Rats, Sprague-Dawley
Shivering / physiology
Thermogenesis / physiology*
Vasoconstrictor Agents / pharmacology
Grant Support
ID/Acronym/Agency:
MH28355/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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