| Rat acetoacetate decarboxylase: its role in the disposal of 4C-ketone bodies by the fetus. | |
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MedLine Citation:
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PMID: 3744292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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21-day pregnant rats show high tissular and plasmatic acetone concentrations when submitted to a 48-hr fast. This rise is, in fact, associated with an enhanced placental and fetal acetoacetate decarboxylase activity. We propose that acetone formation by the fetus could be a mechanism for pH maintenance and that acetoacetate decarboxylase can play a significant role in the handling of 4C-ketone bodies under conditions in which the substrate concentration cannot easily be controlled by other physiological mechanisms. |
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Authors:
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F J López-Soriano; J M Argilés |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 18 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-10-21 Completed Date: 1986-10-21 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 446-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetone
/
analysis,
metabolism Animals Carboxy-Lyases / metabolism* Fasting Female Fetus / enzymology* Hydrogen-Ion Concentration Ketone Bodies / metabolism* Placenta / enzymology Pregnancy Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Ketone Bodies; 67-64-1/Acetone; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.4/acetoacetate decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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