Document Detail


A rat model system to study complex disease risks, fitness, aging, and longevity.
MedLine Citation:
PMID:  22867966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association between low exercise capacity and all-cause morbidity and mortality is statistically strong yet mechanistically unresolved. By connecting clinical observation with a theoretical base, we developed a working hypothesis that variation in capacity for oxygen metabolism is the central mechanistic determinant between disease and health (aerobic hypothesis). As an unbiased test, we show that two-way artificial selective breeding of rats for low and high intrinsic endurance exercise capacity also produces rats that differ for numerous disease risks, including the metabolic syndrome, cardiovascular complications, premature aging, and reduced longevity. This contrasting animal model system may prove to be translationally superior relative to more widely used simplistic models for understanding geriatric biology and medicine.
Authors:
Lauren Gerard Koch; Steven L Britton; Ulrik Wisløff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-08-04
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  22     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2013-02-19     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA. lgkoch@med.umich.edu
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Disease Models, Animal
Exercise Tolerance / physiology
Longevity / physiology*
Oxygen Consumption
Physical Conditioning, Animal / physiology*
Rats
Risk Assessment / methods
Grant Support
ID/Acronym/Agency:
P30 AG024824/AG/NIA NIH HHS; P30 AG13283/AG/NIA NIH HHS; R01 DK077200/DK/NIDDK NIH HHS; R0D012098A//PHS HHS; R24 RR017718/RR/NCRR NIH HHS; R24 RR017718/RR/NCRR NIH HHS
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