Document Detail

Rash from antiepileptic drugs: influence by gender, age, and learning disability.
MedLine Citation:
PMID:  17484761     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Cutaneous adverse reactions from antiepileptic drugs (AEDs) are common, but have received little scientific attention from a clinical point of view. We wanted to study the incidence of skin reactions of current AEDs and to explore their relation to clinical parameters such as gender, age, and learning disability.
METHODS: Consecutive patients with epilepsy were studied retrospectively. A detailed survey of medical records concerning all treatment with AEDs was performed.
RESULTS: A total of 663 patients were included with altogether 2,567 exposures to 15 different AEDs. Skin reactions were found in 14% of the patients and in 5% of the exposures. Ninety-seven percent of the reactions occurred to either carbamazepine (CBZ, 11%), phenytoin (PHT, 8%), lamotrigine (LTG, 8%), oxcarbazepine (8%), or phenobarbital (2%). Skin reactions developed significantly more often in females than in males (19% vs. 8%), and significantly less often in patients with learning disability than in other patients (7% vs. 16%). These differences were significant for CBZ, PHT, and LTG when analyzed separately. Females displayed higher rash frequency during the reproductive years, while men experienced less frequent rash in the same phase of life.
CONCLUSIONS: Fertile females have a higher risk for skin reactions compared to males, probably due to hormonal factors. Patients with learning disability appeared to have a lower risk than other patients in this study. Hygiene factors may possibly be underlying.
Silje Alvestad; Stian Lydersen; Eylert Brodtkorb
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-05-01
Journal Detail:
Title:  Epilepsia     Volume:  48     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-08-09     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1360-5     Citation Subset:  IM    
Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
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MeSH Terms
Age Factors
Anticonvulsants / adverse effects*,  therapeutic use
Carbamazepine / adverse effects,  therapeutic use
Drug Eruptions / epidemiology,  etiology*
Epilepsy / drug therapy*,  epidemiology*
Learning Disorders / epidemiology*
Phenytoin / adverse effects,  therapeutic use
Retrospective Studies
Risk Factors
Sex Factors
Triazines / adverse effects,  therapeutic use
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; 298-46-4/Carbamazepine; 57-41-0/Phenytoin; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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