| Rash, Hepatotoxicity and Hyperbilirubinemia among Kenyan Infants Born to HIV-Infected Women Receiving Triple-Antiretroviral Drugs for the Prevention of Mother-to-Child HIV Transmission. | |
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MedLine Citation:
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PMID: 22772167 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We compared adverse events among breastfeeding neonates born to Kenyan mothers receiving triple-antiretroviral therapy including either nevirapine or nelfinavir. Nevirapine-exposed infants had an absolute increase in risk for rash but no significant risk differences for hepatotoxicity or high-risk hyperbilirubinemia compared with nelfinavir-exposed infants. From an infant-safety perspective, nevirapine-based regimens given during pregnancy and breastfeeding are viable options where alternatives to breast milk are not safe, affordable, or feasible. |
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Authors:
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Timothy D Minniear; Clement Zeh; Nicholas Polle; Rose Masaba; Philip J Peters; Boaz Oyaro; Benta Akoth; Richard Ndivo; Frank Angira; Lisa A Mills; Timothy K Thomas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-5 |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: - ISSN: 1532-0987 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Epidemic Intelligence Service, CDC, Atlanta, GA, USA; 2Division of HIV/AIDS Prevention, CDC, Atlanta, GA, USA; 3Kenya Medical Research Institute/CDC Research and Public Health Collaboration, Kisumu, Kenya; 4Ministry of Health Kenya, Nairobi, Kenya. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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