Document Detail


Rash, Hepatotoxicity and Hyperbilirubinemia among Kenyan Infants Born to HIV-Infected Women Receiving Triple-Antiretroviral Drugs for the Prevention of Mother-to-Child HIV Transmission.
MedLine Citation:
PMID:  22772167     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We compared adverse events among breastfeeding neonates born to Kenyan mothers receiving triple-antiretroviral therapy including either nevirapine or nelfinavir. Nevirapine-exposed infants had an absolute increase in risk for rash but no significant risk differences for hepatotoxicity or high-risk hyperbilirubinemia compared with nelfinavir-exposed infants. From an infant-safety perspective, nevirapine-based regimens given during pregnancy and breastfeeding are viable options where alternatives to breast milk are not safe, affordable, or feasible.
Authors:
Timothy D Minniear; Clement Zeh; Nicholas Polle; Rose Masaba; Philip J Peters; Boaz Oyaro; Benta Akoth; Richard Ndivo; Frank Angira; Lisa A Mills; Timothy K Thomas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-5
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Epidemic Intelligence Service, CDC, Atlanta, GA, USA; 2Division of HIV/AIDS Prevention, CDC, Atlanta, GA, USA; 3Kenya Medical Research Institute/CDC Research and Public Health Collaboration, Kisumu, Kenya; 4Ministry of Health Kenya, Nairobi, Kenya.
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