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Ras p21 overexpression is a late event in prostate-cancer.
MedLine Citation:
PMID:  21566969     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Several lines of evidence implicate the ras oncogene in tumorigenesis. However, changes in ras oncogene is uncommon in prostate cancer. We evaluated tumors from 55 patients with metastatic prostate cancer (50 lymph nodes, 5 bone metastases), 10 patients with localized cancers and 35 diethylstilbestrol treated primary tumors. Also, 15 patients with benign prostatic hyperplasia and 23 with prostatic intraepithelial neoplasia (PIN) were investigated for ras p21 expression. Avidin biotin immunoperoxidase was used on formalin-fixed, paraffin-embedded tissues with the Pan-ras (Ab-1) monoclonal antibody. Antibody titration demonstrated expression of ras p21 in none of the benign, PIN or DES-treated primary tumor specimens. However, 30% of untreated primary tumors and 94.5% of metastatic tumors (94% of lymph node metastases, 100% of bone metastases) showed expression (p=0.00002). Semi-quantitative evaluation of ras protein expression revealed a significant correlation with Gleason score in lymph node metastases (p=0.001). This study suggests a possible role of ras oncogene in prostate cancer progression, metastasis and androgen independency.
Authors:
S Hamdy; A Aprikian; L Begin; W Fair; M Bazinet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oncology     Volume:  4     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  2011-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  627-31     Citation Subset:  -    
Affiliation:
MCGILL UNIV,MONTREAL GEN HOSP,DEPT UROL,1650 CEDAR,MONTREAL H3G 1A4,QUEBEC,CANADA. MCGILL UNIV,MONTREAL GEN HOSP,DEPT PATHOL,MONTREAL H3G 1A4,QUEBEC,CANADA. MEM SLOAN KETTERING CANC CTR,UROL SERV,NEW YORK,NY 10021.
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