Document Detail

Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites.
MedLine Citation:
PMID:  23060054     Owner:  NLM     Status:  MEDLINE    
The gastrointestinal tract is habitable by a variety of microorganisms and it is often a tissue inflicted by inflammation. Much discussion is raised in recent years about the role of microbiota in intestinal inflammation, but their role in intestinal cancer remains unclear. Here we discuss and extent our work on Drosophila melanogaster models of tumorigenesis and tumor cell invasion upon intestinal infection. In Drosophila midgut bacteria that cause enterocyte damage induce intestinal stem cell proliferation, which is diverted toward aberrant stem cell expansion upon oncogene expression to induce dysplastic tumors. In the hindgut though, oncogenes synergize with the innate immune response-not the bacterially mediated damage-to induce tumor cell invasion and dissemination to distant sites. Interestingly, our novel gene expression analysis of Drosophila hemocyte-like cells suggests commonalities with oncogenic hindgut cells in the innate immune response and the expression of matrix metalloproteinase 1 in response to bacterial infection.
Theodoulakis Christofi; Yiorgos Apidianakis
Related Documents :
23012424 - Sam-pointed domain ets factor mediates epithelial cell-intrinsic innate immune signalin...
23914844 - 8β-hydroxy-3-oxopimar-15-ene exerts anti-inflammatory effects by inhibiting ros-mediat...
21787354 - Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases.
22961094 - Increased nuclear thioredoxin-1 potentiates cadmium-induced cytotoxicity.
7515094 - Comparison of biological responses of human monocytes and thp-1 cells to chemokines of ...
23820884 - Bacterial colonization dampens influenza-mediated acute lung injury via induction of m2...
Publication Detail:
Type:  Journal Article; Review     Date:  2012-10-12
Journal Detail:
Title:  Gut microbes     Volume:  4     ISSN:  1949-0984     ISO Abbreviation:  Gut Microbes     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-07-03     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495343     Medline TA:  Gut Microbes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Proliferation
Disease Models, Animal
Drosophila melanogaster*
Enteritis / complications*,  microbiology*,  pathology
Enterocytes / microbiology
Gastrointestinal Tract / microbiology*,  physiology*
Gene Expression Profiling
Immunity, Innate
Inflammation / immunology,  pathology
Intestinal Neoplasms / etiology*,  microbiology*
Matrix Metalloproteinase 1 / biosynthesis
Stem Cells / microbiology
Reg. No./Substance:
EC Metalloproteinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cystic fibrosis transmembrane conductance regulator knockout mice exhibit aberrant gastrointestinal ...
Next Document:  Synthesis and Photoluminescence Properties of Eu(3+) -Doped Silica@Coordination Polymer Core-Shell S...