Document Detail


Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer.
MedLine Citation:
PMID:  19896097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) is unclear. CP is a risk factor for PDAC, CP is found within the vicinity of PDAC, and both share many similar genetic alterations. However, it has been long thought that PDAC arises only from duct cells. However, we have recently found that excessive activity within the Ras signaling pathway can lead to acinar cell death or metaplasia and is associated with the development of fibrosis resembling CP and the development of PDAC from acinar cells through the full complement of preneoplastic (pancreatic intraepithelial neoplasia) lesions. Therefore, it is time to reevaluate the relationship between CP and PDAC. We proposed a new model in which Ras activity is the direct link between these 2 diseases. Here we will briefly review the shared properties between CP and PDAC and describe the new model.
Authors:
Craig D Logsdon; Baoan Ji
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  7     ISSN:  1542-7714     ISO Abbreviation:  Clin. Gastroenterol. Hepatol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-02-12     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S40-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / etiology*,  pathology*
Carcinoma, Pancreatic Ductal / etiology*,  pathology*
Genes, ras*
Humans
Models, Biological
Pancreatitis, Chronic / complications*,  pathology*
Signal Transduction
Grant Support
ID/Acronym/Agency:
5R21DK068414/DK/NIDDK NIH HHS; CA16672/CA/NCI NIH HHS; DK052067/DK/NIDDK NIH HHS; P20 CA101936/CA/NCI NIH HHS; R01 AA020822/AA/NIAAA NIH HHS; R01 DK052067/DK/NIDDK NIH HHS; R01 DK052067-11/DK/NIDDK NIH HHS
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