| Ras activity in acinar cells links chronic pancreatitis and pancreatic cancer. | |
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MedLine Citation:
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PMID: 19896097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) is unclear. CP is a risk factor for PDAC, CP is found within the vicinity of PDAC, and both share many similar genetic alterations. However, it has been long thought that PDAC arises only from duct cells. However, we have recently found that excessive activity within the Ras signaling pathway can lead to acinar cell death or metaplasia and is associated with the development of fibrosis resembling CP and the development of PDAC from acinar cells through the full complement of preneoplastic (pancreatic intraepithelial neoplasia) lesions. Therefore, it is time to reevaluate the relationship between CP and PDAC. We proposed a new model in which Ras activity is the direct link between these 2 diseases. Here we will briefly review the shared properties between CP and PDAC and describe the new model. |
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Authors:
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Craig D Logsdon; Baoan Ji |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Volume: 7 ISSN: 1542-7714 ISO Abbreviation: Clin. Gastroenterol. Hepatol. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-09 Completed Date: 2010-02-12 Revised Date: 2013-02-04 |
Medline Journal Info:
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Nlm Unique ID: 101160775 Medline TA: Clin Gastroenterol Hepatol Country: United States |
Other Details:
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Languages: eng Pagination: S40-3 Citation Subset: IM |
Affiliation:
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Department of Cancer Biology and GI Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. clogsdon@mdanderson.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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etiology*,
pathology* Carcinoma, Pancreatic Ductal / etiology*, pathology* Genes, ras* Humans Models, Biological Pancreatitis, Chronic / complications*, pathology* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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5R21DK068414/DK/NIDDK NIH HHS; CA16672/CA/NCI NIH HHS; DK052067/DK/NIDDK NIH HHS; P20 CA101936/CA/NCI NIH HHS; R01 AA020822/AA/NIAAA NIH HHS; R01 DK052067/DK/NIDDK NIH HHS; R01 DK052067-11/DK/NIDDK NIH HHS; R01 DK052067-13/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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