Document Detail


Ras, ROS and proteotoxic stress: a delicate balance.
MedLine Citation:
PMID:  21907917     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functioning stress response machinery. In this issue of Cancer Cell, De Raedt et al. identify a novel strategy that utilizes this dependency to cause cell death.
Authors:
Wanping Xu; Jane Trepel; Len Neckers
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cancer cell     Volume:  20     ISSN:  1878-3686     ISO Abbreviation:  Cancer Cell     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-12     Completed Date:  2011-11-07     Revised Date:  2012-09-28    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  281-2     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Urologic Oncology Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
Z01 SC010074-12/SC/NCI NIH HHS; Z99 CA999999/CA/NCI NIH HHS; ZIA SC010074-14/SC/NCI NIH HHS; ZIA SC010074-15/SC/NCI NIH HHS
Comments/Corrections
Comment On:
Cancer Cell. 2011 Sep 13;20(3):400-13   [PMID:  21907929 ]

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