Document Detail

Rarity of IgH translocations in Waldenström macroglobulinemia.
MedLine Citation:
PMID:  16271961     Owner:  NLM     Status:  MEDLINE    
Comparatively little is known of the cytogenetics of Waldenström macroglobulinemia (WM). This is primarily due to the low proliferation of the clonal B cells, which precludes conventional karyotyping in many cases. Translocations involving the immunoglobulin heavy chain (IGH) gene at 14q32 are characteristic of many B-cell lymphomas and myelomas. Initial reports suggested that the t(9;14) was characteristic of lymphoplasmacytic lymphoma (the underlying pathological diagnosis in WM), but subsequent studies have failed to confirm the uniqueness of the translocation. To clarify this, we examined 69 cases of WM with interphase fluorescence in situ hybridization and failed to demonstrate an IgH translocation in 67 (97%). We conclude that IGH translocations are not a feature of WM, and the implications of this finding are discussed.
Sam Ackroyd; Sheila J M O'Connor; Roger G Owen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  163     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-07     Completed Date:  2006-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
HMDS Laboratory, The Leeds Teaching Hospitals NHS Trust, Leeds LSI 3EX, United Kingdom.
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MeSH Terms
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 14*
Chromosomes, Human, Pair 9
Immunoglobulin Heavy Chains / genetics*
In Situ Hybridization, Fluorescence
Nucleic Acid Hybridization
Translocation, Genetic*
Waldenstrom Macroglobulinemia / genetics*
Reg. No./Substance:
0/Immunoglobulin Heavy Chains

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