Document Detail


Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality.
MedLine Citation:
PMID:  10523342     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recently showed that rarefaction of skin capillaries in the dorsum of the fingers of patients with essential hypertension is due to the structural (anatomic) absence of capillaries rather than functional nonperfusion. It is not known whether this rarefaction is primary (ie, antedates the onset of hypertension) or secondary (ie, as a consequence of sustained and prolonged elevation of blood pressure [BP]). The aim of the present investigation was to study skin capillary density in a group of patients with mild borderline hypertension to assess whether rarefaction antedates the onset of sustained elevation of BP. The study group included 18 patients with mild borderline hypertension (mean supine BP, 136/83 mm Hg), 32 normotensive controls (mean BP, 126/77 mm Hg), and 45 patients with established essential hypertension (mean BP, 156/98 mm Hg). The skin of the dorsum of the fingers was examined by intravital capillary videomicroscopy before and after venous congestion at 60 mm Hg for 2 minutes. Patients with borderline essential hypertension had the lowest resting capillary density when compared with normotensive controls and patients with established hypertension. Maximal capillary density with venous congestion in the borderline group remained the lowest. The study confirmed that patients with borderline essential hypertension have skin capillary densities that are equally low as or even lower than patients with established hypertension. Both groups had significantly lower capillary densities than normal controls. One explanation for the results is that capillary rarefaction may be due to an early structural abnormality in essential hypertension.
Authors:
T F Antonios; D R Singer; N D Markandu; P S Mortimer; G A MacGregor
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  34     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-01     Completed Date:  1999-12-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  655-8     Citation Subset:  IM    
Affiliation:
Blood Pressure Unit, Department of Medicine, St. George's Hospital Medical School, London, UK. tantonios@sghms.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Blood Pressure
Capillaries / pathology
Case-Control Studies
Female
Fingers / blood supply*
Humans
Hypertension / pathology*,  physiopathology
Male
Microscopy, Video
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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