Document Detail

Rare sensory and autonomic disturbances associated with vitamin B12 deficiency.
MedLine Citation:
PMID:  19720386     Owner:  NLM     Status:  MEDLINE    
Vitamin B12 deficiency is an important nutritional disorder causing neurological manifestations of myelopathy, neuropathy and dementia. Sub-acute combined degeneration (SCD) with involvement of the posterior columns in the cervical and thoracic cord is a common presentation of this disorder. In this case report, we describe a 43 year old woman with pernicious anemia and myelopathy with atypical clinical features. The patient presented with motor symptoms, a sensory level and bladder dysfunction. She had severe autonomic disturbances including an episode of unexplained bronchospasm, which has not been previously reported as a manifestation of vitamin B12 deficiency. We review the literature regarding these rarely reported features of vitamin B12 deficiency, and discuss aspects of management of this reversible condition. We emphasize the importance of awareness of autonomic disturbances in B12 deficient individuals.
Preeti Puntambekar; Maysaa M Basha; Imad T Zak; Ramesh Madhavan
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-08-31
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  287     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  285-7     Citation Subset:  IM    
Department of Neurology, Wayne State University School of Medicine/Detroit Medical Center, 4201 St Antoine, Detroit, MI 48201, United States.
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MeSH Terms
Anemia, Pernicious / etiology,  metabolism
Autonomic Nervous System Diseases / etiology*,  pathology,  physiopathology
Bronchi / innervation,  physiopathology
Bronchial Spasm / etiology,  physiopathology
Leg / innervation,  physiopathology
Magnetic Resonance Imaging
Muscle, Skeletal / innervation,  physiopathology
Neural Pathways / metabolism,  pathology,  physiopathology
Paraparesis / etiology,  physiopathology
Sensation Disorders / etiology,  physiopathology
Spinal Cord / metabolism,  pathology,  physiopathology
Spinal Cord Diseases / etiology*,  pathology,  physiopathology
Subacute Combined Degeneration / etiology*,  pathology,  physiopathology
Sympathetic Nervous System / metabolism,  pathology,  physiopathology
Treatment Outcome
Urinary Bladder, Neurogenic / etiology,  physiopathology
Vitamin B 12 / administration & dosage
Vitamin B 12 Deficiency / complications*,  drug therapy
Reg. No./Substance:
68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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