| Rare pneumoconiosis induced by long-term amorphous silica exposure: The histological characteristics and expression of cyclooxygenase-2 as an antifibrogenic mediator in macrophages. | |
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MedLine Citation:
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PMID: 22029678 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Pneumoconiosis induced by non-crystalline silica is considered rare, although silicosis resulting from contact with crystalline silica is a well-known hazard associated with progressive pulmonary fibrosis. Here we describe a patient with pneumoconiosis induced by diatomaceous earth composed of amorphous silica detected by two-dimensional imaging of chemical elements. The histology revealed that the disease was characterized by a granulomatous reaction in the lung. A large number of macrophages laden with yellow and black pigments accumulated in alveolar spaces and were incorporated into the interstitial sites. Bronchiolar walls were destroyed by palisade macrophages, suggesting airflow obstruction. Packed macrophages adhering to and covering the denuded interstitium indicated that macrophages might be incorporated into pulmonary interstitium in this fashion. Immunohistochemistry showed that cyclooxygenase-2, an antifibrogenic mediator, was intensely expressed in the macrophages compared with macrophages in control lungs. No birefringent material was found in the tissues. When two-dimensional analysis of chemical elements was performed using an electron probe microanalyzer with a wavelength-dispersive spectrometer, the resultant fine mapping of silicon and oxygen on the tissue indicated that the pigments phagocytosed by macrophages corresponded to amorphous silica. In conclusion, two-dimensional analysis of elements is very useful for pathologists in correlating the presence of chemical elements with histological changes. |
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Authors:
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Toshio Kumasaka; Yasushi Akaike; Osamu Nakamura; Kazuma Yamazaki; Hiroshi Moriyama; Tamiko Takemura |
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Publication Detail:
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Type: Journal Article Date: 2011-09-07 |
Journal Detail:
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Title: Pathology international Volume: 61 ISSN: 1440-1827 ISO Abbreviation: Pathol. Int. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: Australia |
Other Details:
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Languages: eng Pagination: 667-71 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of Pathology, Japanese Red Cross Medical Center, Tokyo Division of Clinical Pathology Department of Internal Medicine Department of Surgery, Shimotsuga General Hospital, Tochigi Department of Respiratory Medicine, Niigata University School of Medicine, Niigata, Japan. |
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