Document Detail

Rare normalization of blood pressure after unilateral adrenalectomy in 31 patients with Conn syndrome.
MedLine Citation:
PMID:  17256139     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adrenal tumor excision in patients with Conn syndrome is not always followed by normalization of blood pressure (BP). The aim of the study was to determine predictors of persistent hypertension during long-term observation after adrenalectomy. MATERIALS AND METHODS: Thirty-one patients (23 F and 8 M) with Conn syndrome and adrenal tumor subjected to unilateral adrenalectomy were included. The duration of hypertension ranged from 1 to 30 years and observation time from 1 to 10 years. RESULTS: Beneficial impact of adrenalectomy on BP control was found in 25 patients, including only 10 patients with BP normalization. Patients with normalization of BP were significantly younger [41 (36-46) vs 53 (48-57) years; p = 0.002] and had lower pulse BP [72 (56-89) vs 93(80-106) mmHg; p = 0.03]. Significant decline of maximal values of systolic and diastolic BP after surgery was observed [59 (47-72) and 29 (20-37) mmHg, respectively]. The analysis revealed that age over 50 years and pulse BP over 70 mmHg predict the persistence of hypertension after surgery. CONCLUSION: Normalization of BP after adrenalectomy is observed only in 32% of patients with Conn syndrome regardless the normalization of hypokalemia. BP normalization in long period observation was more frequently found in younger patients with lower pulse BP.
Jacek Ziaja; Jerzy Chudek; Robert Król; Jacek Pawlicki; Andrzej Wiecek; Lech Cierpka
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Publication Detail:
Type:  Journal Article     Date:  2007-01-26
Journal Detail:
Title:  Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie     Volume:  392     ISSN:  1435-2443     ISO Abbreviation:  Langenbecks Arch Surg     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-12     Completed Date:  2007-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808285     Medline TA:  Langenbecks Arch Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  IM    
Department of General, Vascular and Transplant Surgery, Medical University of Silesia, ul. Francuska 20-24, 40-027 Katowice, Poland.
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MeSH Terms
Age Factors
Blood Pressure*
Hyperaldosteronism / physiopathology*
Hypertension / epidemiology
Middle Aged
Postoperative Complications / epidemiology
Postoperative Period
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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