Document Detail

Rare immediate hypersensitivity to rifampicin in a patient with tuberculosis requiring drug discontinuation.
MedLine Citation:
PMID:  23060374     Owner:  NLM     Status:  Publisher    
A 47-year-old Turkish female patient was diagnosed with tuberculosis of the sacro-iliac joints and terminal ileum. She developed a severe adverse drug reaction while taking first-line tuberculosis therapy consisting of isoniazid, pyrazinamide and rifampicin as Rifater and ethambutol. Within 5 min of ingestion she developed pruritic rash, angioedema and breathing difficulties, resulting in an A&E admission. The tuberculosis therapy was discontinued. Intradermal and oral challenge tests for rifampicin were conducted but abandoned early on due to reactions which included audible wheeze, vomiting, throat pain and violent rigours. Clinical manifestations were swiftly treated with appropriate medications. This resulted in a change to the tuberculosis treatment regime, where streptomycin, isoniazid, ethambutol and pyrazinamide were given for 2 months and isoniazid and ethambutol for 12 months. Allergic reactions to rifampicin are rare and should be distinguished from flushing due to pyrazinamide. Prompt diagnosis and treatment by clinicians can be life saving.
Nima Farah; Andrew Williams; Michelle Joyce; Graham H Bothamley; K Rajakulasingam
Related Documents :
23056934 - Epileptic encephalopathies in adults and childhood.
20803624 - Original and efficient synthesis of d-cycloserine.
25092764 - Drug shows efficacy in neoplastic joint disorder.
21098684 - Appetite-regulating hormones cortisol and peptide yy are associated with disordered eat...
17878494 - Should conversion disorder be reclassified as a dissociative disorder in dsm v?
8362904 - Brachydactylous dwarfs of mseleni.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  BMJ case reports     Volume:  2012     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Respiratory Medicine/Allergy, Homerton University Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cervical pedicle screw fixation in traumatic cervical subluxation after laminectomy using the pedicl...
Next Document:  An unusual cause for recurrent chest infections.