|Rare early prosthesis obstruction after mitral valve replacement: a case report and literature review.|
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|PMID: 22747990 Owner: NLM Status: MEDLINE|
|As a dreadful complication after the mechanical heart valve replacement, prosthetic valve obstruction caused by pannus formation occurs increasingly with time. The authors here present a case of 42-year-old woman who was urgently admitted to hospital with acute heart failure symptoms due to the mechanical mitral valve failure only 3 months after surgery. Transthoracic and transesophageal echocardiography demonstrated that the bileaflet of the mitral prosthesis were completely immobilized with only a small transvalvular jet remained. During the reoperation, the reason of the prosthetic valve obstruction was attributed to the noncircular pannus ingrowth extending from the atrioventricular side. For a better understanding of the prosthetic valve dysfunction caused by pannus formation, the authors then compile a literature review to briefly discuss the status quo of the clinical characteristics of this uncommon complication.|
|Jun Shi; Zhi-xuan Bai; Jia Hu; Ben-gui Zhang; Ying-qiang Guo|
|Type: Case Reports; Journal Article Date: 2012-07-02|
|Title: Journal of cardiothoracic surgery Volume: 7 ISSN: 1749-8090 ISO Abbreviation: J Cardiothorac Surg Publication Date: 2012|
|Created Date: 2012-11-01 Completed Date: 2013-01-07 Revised Date: 2013-07-12|
Medline Journal Info:
|Nlm Unique ID: 101265113 Medline TA: J Cardiothorac Surg Country: England|
|Languages: eng Pagination: 64 Citation Subset: IM|
|Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Cheng Du, People's Republic of China.|
|APA/MLA Format Download EndNote Download BibTex|
Heart Valve Prosthesis Implantation*
Mitral Valve / cytology, pathology, surgery*, ultrasonography
Journal ID (nlm-ta): J Cardiothorac Surg
Journal ID (iso-abbrev): J Cardiothorac Surg
Publisher: BioMed Central
Copyright ©2012 Shi et al.; licensee BioMed Central Ltd.
Received Day: 9 Month: 12 Year: 2011
Accepted Day: 19 Month: 5 Year: 2012
collection publication date: Year: 2012
Electronic publication date: Day: 2 Month: 7 Year: 2012
Volume: 7First Page: 64 Last Page: 64
PubMed Id: 22747990
Publisher Id: 1749-8090-7-64
|Rare early prosthesis obstruction after mitral valve replacement: a case report and literature review|
|Jun Shi1||Email: firstname.lastname@example.org|
|Zhi-xuan Bai1||Email: email@example.com|
|Jia Hu1||Email: firstname.lastname@example.org|
|Ben-gui Zhang1||Email: Bengui.Zhang@hotmail.com|
|Ying-qiang Guo1||Email: email@example.com|
1Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Cheng Du, People’s Republic of China
The evolving design and biomaterials of the mechanical heart valves have greatly advanced their in vivo hemodynamic features and durability over decades . However, the anticipated performances of the mechanical prostheses are still compromised by the occurrence of various complications, among which pannus-induced prosthetic valve dysfunction (PVD) is relatively uncommon but sometimes is the most serious one [2,3]. In particular, patients with prosthetic valve obstruction (PVO) due to pannus ingrowth may rapidly develop hemodynamic deterioration and crash into a life-threatening condition. According to recent studies [2,4-7], the prevalence of pannus formation in aortic or mitral position is controversial. However, pannus is undoubtedly of later clinical onset than the thrombosis, which is mostly responsible for the early PVD. Moreover, the duration from time of prostheses implantation to pannus-induced PVD is widely variable and has been reported to be at least 6 months to 12 months, during which an ingrowth of periannular tissue would gradually immobilize the moving element of the prostheses [6-8]. Here we present a rare case of PVO in the mitral position caused by early pannus formation only 3 months after surgery.
A 42-year-old woman was admitted to our intensive cardiac care unit with symptoms of acute left heart failure. Three months prior to admission, she underwent the implantation of a mechanical bileaflet mitral valve (25 mm SJM Master; St. Paul, MN, USA) due to severe rheumatic valve stenosis. No native valve- or chordal-sparing procedures were performed during the replacement. The postoperative course went smoothly and transthoracic echocardiography (TTE) showed proper functioning of the prosthesis. The patient then followed adequate anticoagulation treatment with wafarin and the international normalized ratio maintained above 2.0. No episode of atrial fibrillation and other risk factors for thrombus formation were identified. One week before this admission, she had noticed a progressive physical deterioration. After the treatment at local hospital, the patient showed no signs of recovery and finally presented with severe shortness of breath and coughing up pink, foamy mucus on the arrival of our hospital.
On admission, the patient was conscious but presented with marked respiratory distress. Initial vital signs showed blood pressure 80/40 mmHg, sinus rhythm, a regular pulse of 140 beats/min and a respiratory rate of 40 breaths/min. Auscultation of the chest revealed diffuse rhonchi and expiratory wheezes without any distinct heart murmurs. No signs of jugular venous distention and extremities edema were observed. The patient was intubated due to the deteriorated respiratory status. After intubation, bedside TTE demonstrated that the prosthetic bileaflet was immobilized and only a small transvalvular jet was observed. However, no paravalvular leakage, and vegetations or periannular abscesses that indicating endocarditis were identified (Figure 1A).
In view of the patient’s unstable hemodynamic conditions and echocardiographic findings, an emergent surgical intervention was performed. Intraoperative transesophageal echocardiography (TEE) demonstrated the immobilization of the prosthetic leaflets, which might be attributed to the acoustic shadowing around the valve ring (Figure 1B and Figure 1C). During surgical inspection, a noncircular fibrotic tissue ingrowth from the atrioventricular side was detected. The invaded pannus strictly adhered to the valve pivots and arrested both prosthetic leaflets (Figure 2). The failed prosthesis was explanted and a new 27 mm SJM Master mechanical valve was implanted. The postoperative course was regular and in-hospital TTE showed normal functioning of the newly implanted mitral prosthesis. The patient had an uneventful recovery and was discharged home at two weeks after surgery.
On microscopic examination (Figure 3), the resected pannus tissue was found to be mainly constituted with infiltrated leukocytes (neutrophils, macrophages, lymphocytes and plasma cells), pleomorphic spindle cells such as myofibroblasts, and interspersed capillary vessels.
As an exuberant healing process in response to the implanted prosthesis, pannus formation occurs increasingly with time. Compared with valvular thrombosis, pannus is less frequently found to be an etiologic factor that contributes to the early PVD [2-8]. According to multiple clinical observations (Table 1), the duration from the time of prostheses implantation to pannus-induced PVD varies widely and has been reported to be 1.8 years to 23 years after surgery [4-7,9,10], and a shorter time interval (6 months) has been described in patient with the prosthetic aortic valve . However, in this case, the time interval from the initial replacement to PVO caused by pannus ingrowth was extraordinarily short. To our best knowledge, there were no reports of pannus-induced PVO within one year after mitral valve replacement .
The cause of the pannus-related PVD and PVO is generally considered as a chronic foreign body reaction to the prosthetic biomaterials. It is likely that an individual patient’s inherent propensity with coexisting risk factors triggers and accelerates the progression of pannus formation. These associated factors can be summarized as follows: 1) Clinical characteristics of the patients: female, concomitant endocarditis and pregnancy, the history of rheumatic fever and valvular thrombosis, atrial fibrillation, low-output conditions, small valve annulus and inadequate anticoagulation [2,5-9] Design and biomaterials of the prostheses: tilting disc valves and caged-disk/ball valves due to low transvalvular flow [7,11,14], the protruding design of the pivot guard systems in the SJM valves [3,15] Surgical techniques: preservation of the native valve or subvalvular chordae [12,13], implantation of the prostheses with smaller size , the presence of periannular endothelial irregularities after implantation [2,4,7]. Taken together, as presented in our case, the history of severe rheumatic disease, small mitral annulus and implanted SJM prosthesis in this female patient may have contributed to the acute formation of the pannus.
The underlying mechanism of the pannus formation was supposed to be the significant proliferation and deposition of myofibroblasts, phagocytes and extracellular matrix, which are mediated by increased expression of transforming growth factor type beta-1 (TGF-β1) in perivalvular tissue and circulating blood [5,16]. Moreover, some studies have suggested that the persistent release of fibroblast growth factor-2 (FGF-2) from the injured periannular tissue may also contribute to this chronic healing process . Therefore, echo to these important observations, a promising therapeutic strategy to prevent pannus formation in high risk patients might be achieved by suppressing the proliferative responses in periannular tissues with the drug-coated prostheses.
The obstruction of prosthetic valves is largely caused by pannus, thrombus or both, so it is of great therapeutic implications to make differential diagnosis on them. Because reopen heart surgery, either repeated valve replacement or resection of the ingrowth tissue , is the only option for managing the pannus-induced PVO, while thrombolytic therapy can serve as an alternative treatment in selected patients with thrombosed prostheses [18,19]. As reported in several echocardiographic studies, pannus in situ presents with a higher ultrasound-intensity ratio (>0.7)  and is usually found to be a fixed lesion that attaches to the prosthetic ring . Conversely, the thrombotic mass demonstrated in echo is mobile and is generally attaching to the valve occluder [1,2,20]. Although thrombolysis may be preferred for its less invasiveness in certain group of patients, surgical intervention, as for this case, should be unhesitatingly performed once the patients show any signs of hemodynamic instability.
With adequate anticoagulation and no preservation of subvalvular tissue in the first-time mitral valve replacement, the pannus-induced obstruction of an SJM bileaflet mechanical valve within such a short time interval was very uncommon. This rare case has added to a growing body of literatures describing the various clinical features of the pannus-related PVO. Further explorations on etiologic-specified prevention, and efficient treatment for this complication are required.
Written informed consent was obtained from the patient for publication of this case presentation and accompanying images. A copy of the written consent is available for review by the Editor-in-chief of this journal.
The authors declare that they have no competing interests.
All authors contributed equally to the manuscript and all authors read and approved the final manuscript.
|Aslam AK,Aslam AF,Vasavada BC,Khan IA,Prosthetic heart valves: types and echocardiographic evaluationInt J CardiolYear: 20071229911010.1016/j.ijcard.2006.12.03717434628|
|Hurwitz SE,Waxman D,Hecht S,Acute failure of a St. Jude's prosthetic aortic valve: large pannus formation masked by a small thrombusJ Am Soc EchocardiogrYear: 2009221086e1e319733796|
|Mullenix PS,Parsa CJ,Mackensen GB,Jollis JG,Harrison JK,Hughes GC,Pannus-related prosthetic valve dysfunction and life-threatening aortic regurgitationJ Heart Valve DisYear: 20081766666919137799|
|Vitale N,Renzulli A,Agozzino L,et al. Obstruction of mechanical mitral prostheses: analysis of pathologic findingsAnn Thorac SurgYear: 1997631101110610.1016/S0003-4975(96)01391-49124913|
|Teshima H,Hayashida N,Yano H,et al. Obstruction of St Jude Medical valves in the aortic position: histology and immunohistochemistry of pannusJ Thorac Cardiovasc SurgYear: 200312640140710.1016/S0022-5223(03)00702-512928636|
|Barbetseas J,Nagueh SF,Pitsavos C,Toutouzas PK,Quiñones MA,Zoghbi WA,Differentiating thrombus from pannus formation in obstructed mechanical prosthetic valves: an evaluation of clinical, transthoracic and transesophageal echocardiographic parametersJ Am Coll CardiolYear: 1998321410141710.1016/S0735-1097(98)00385-49809956|
|Rizzoli G,Guglielmi C,Toscano G,et al. Reoperations for acute prosthetic thrombosis and pannus: an assessment of rates, relationship and riskEur J Cardiothorac SurgYear: 199916748010.1016/S1010-7940(99)00124-410456407|
|Kondruweit M,Flachskampf FA,Weyand M,Schmidt J,Achenbach S,Strecker T,Early failure of a mechanical bileaflet aortic valve prosthesis due to pannus: A rare complicationJ Thorac Cardiovasc SurgYear: 200813621321410.1016/j.jtcvs.2008.01.00818603078|
|Sakamoto Y,Hashimoto K,Okuyama H,Ishii S,Shingo T,Kagawa H,Prevalence of pannus formation after aortic valve replacement: clinical aspects and surgical managementJ Artif OrgansYear: 2006919920210.1007/s10047-006-0334-316998706|
|Sugiura T,Koide M,Kunii Y,Umehara N,Pannus formation on St. Jude Medical prosthetic aortic valve 23 years after initial operationEur J Cardiothorac SurgYear: 20083392610.1016/j.ejcts.2008.01.05718313323|
|Matsuyama K,Nakayama T,Hagiwara H,St. Jude prosthetic valve obstruction in the mitral position.Gen Thorac Cardiovasc SurgYear: 20115935035310.1007/s11748-010-0693-921547631|
|Khan NA,Butany J,Leong SW,Rao V,Cusimano RJ,Ross HJ,Mitral valve-sparing procedures and prosthetic heart valve failure: a case reportCan J CardiolYear: 200925e86e8810.1016/S0828-282X(09)70050-919279993|
|Park B,Park PW,Park CK,Transaortic chordae and pannus removal without redo mitral valve replacement in prosthetic mitral valve malfunctionEur J Cardiothorac SurgYear: 2011391057105810.1016/j.ejcts.2010.09.01721036055|
|Durrleman N,Pellerin M,Bouchard D,Hebert Y,Cartier R,Perrault LP,et al. Prosthetic valve thrombosis: twenty-year experience at the Montreal Heart InstituteJ Thorac Cardiovasc SurgYear: 20041271388139210.1016/j.jtcvs.2003.12.01315115997|
|Aoyagi S,Nishimi M,Tayama E,Fukunaga S,Hayashida N,Akashi H,et al. Obstruction of St Jude medical valves in the aortic position: a consideration for pathogenic mechanism of prosthetic valve obstructionCardiovasc SurgYear: 20021033934410.1016/S0967-2109(02)00021-212359404|
|Teshima H,Fukunaga S,Takaseya T,Tomoeda H,Akashi H,Aoyagi S,Obstruction of St. Jude medical valves in the aortic position: plasma transforming growth factor type beta 1 in patients with pannus overgrowthArtif OrgansYear: 20103421021510.1111/j.1525-1594.2009.00800.x20447046|
|Ozeren M,Demirpence O,Han U,Dogan OV,Yucel E,Onal B,Effect of fibroblast growth factor-2 on pannus formation in replacement prosthetic heart valvesJ Heart Valve DisYear: 20041367668015311877|
|Nagy A,Dénes M,Lengyel M,Predictors of the outcome of thrombolytic therapy in prosthetic mitral valve thrombosis: a study of 62 eventsJ Heart Valve DisYear: 20091826827519557981|
|Shapira Y,Herz I,Vaturi M,Porter A,Adler Y,Birnbaum Y,et al. Thrombolysis is an effective and safe therapy in stuck bileaflet mitral valves in the absence of high-risk thrombiJ Am Coll CardiolYear: 2000351874188010.1016/S0735-1097(00)00640-910841238|
|Lin S,Tiong I,Asher C,Murphy M,Thomas J,Griffin B,Prediction of thrombus-related mechanical prosthetic valve dysfunction using transesophageal echocardiographyAm J CardiolYear: 200086109710110.1016/S0002-9149(00)01166-811074206|
Studies of mechanical prosthetic valves obstruction due to pannus formation
|Authors, years, [Ref.]||Type of studies||Position of Valves||Incidence & Time Interval||Risk Factors|
|Vitale et al. , 1997, 
||Case series (n = 1878)
||3.5%, Mean ≥ 4 years
||Female, Tilting-disc valves, Bileaflet valves
|Barbetseas et al. , 1998, 
||Case series (n = 23)
||Mitral &Aortic valves
||More common in aortic position, 178 ± 52 months
|Rizzoli et al. , 1999, 
||Case series (n = 2680)
||Mitral &Aortic &Tricuspid valves
||0.24%/patient/year, Median = 13 years
||Tilting-disc valves, Caged-disk/ball valves
|Teshima et al. , 2003, 
||Case series (n = 615)
||1.95%, Mean = 83 ± 52 months
||Inadequate anticoagulation, SJM valves
|Sakamoto et al. , 2006, 
||Case series (n = 390)
||1.8%, Mean = 10 ± 7.9 years
||Small prostheses size Turbulent Flow
|Kondruweit et al. 2008, 
||A case report
||Small prosthesis size, Rheumatic fever
|Mullenix et al. , 2008, 
||A case report
||Female, A tilting-disc valve
|Hurwitz et al. , 2009, 
||A case report
|Khan et al. , 2009, 
||A case report
||Female, Subvalvular chordae preservation
|Matsuyama et al. 2011, 
||A case report
||Inadequate anticoagulation, female
|Park et al. , 2011, ||A case report||Mitral valve||9 years||Female, Subvalvular chordae preservation|
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