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Rare case of exogenous Candida dubliniensis endophthalmitis: a case report and brief review of the literature.
MedLine Citation:
PMID:  24860628     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Candida dubliniensis is a recently described opportunistic fungal pathogen that rarely infects the eye. Reported cases of C. dubliniensis endophthalmitis have been of endogenous etiology and demonstrated recovery of visual acuity with timely treatment. We herein report an unusual case of severe C. dubliniensis endophthalmitis requiring enucleation.
FINDINGS: This is a retrospective, descriptive case report with a brief literature review. A 41-year-old Caucasian man, with a history of blunt trauma 8 months prior, presented to the emergency department with left eye pain and loss of vision 2 days after complicated cataract surgery. He was first evaluated by an outside ophthalmologist 3 months after trauma for left eye pain and progressive vision loss. He was found to have light perception vision with non-granulomatous anterior uveitis but no sign of ruptured globe. A dense cataract developed while he was treated with topical and subtenon's corticosteroids for which he underwent cataract surgery. Our examination revealed no light perception vision with a relative afferent pupillary defect, elevated intraocular pressure, moderate anterior chamber reaction, pupillary membrane, vitritis, and choroidal thickening on B-scan ultrasonography. Diagnostic vitrectomy revealed purulent vitreal debris, retinal detachment with severe retinal necrosis, and choroidal infiltrates. Operative fungal cultures grew C. dubliniensis. Despite intravitreal and systemic anti-fungal treatment, vision and pain did not improve, resulting in subsequent enucleation.
CONCLUSION: C. dubliniensis endophthalmitis is uncommonly encountered and typically has reasonable visual outcomes. This is the first reported case of C. dubliniensis, likely exogenous endophthalmitis, resulting in enucleation, illustrating the potential virulence of this newly described organism.
Authors:
Brian Douglas McMillan; Gary James Miller; John Nguyen
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Publication Detail:
Type:  Journal Article     Date:  2014-05-02
Journal Detail:
Title:  Journal of ophthalmic inflammation and infection     Volume:  4     ISSN:  1869-5760     ISO Abbreviation:  J Ophthalmic Inflamm Infect     Publication Date:  2014  
Date Detail:
Created Date:  2014-05-26     Completed Date:  2014-05-26     Revised Date:  2014-05-28    
Medline Journal Info:
Nlm Unique ID:  101553216     Medline TA:  J Ophthalmic Inflamm Infect     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  11     Citation Subset:  -    
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