Document Detail


A Rare Presentation of In Situ Mantle Cell Lymphoma and Follicular Lymphoma: A Case Report and Review of the Literature.
MedLine Citation:
PMID:  25478252     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A 65-year-old gentleman presented with left groin swelling over the course of two months. Physical exam revealed nontender left inguinal adenopathy, and computed tomography scans detected multiple lymph nodes in the mesenteric, aortocaval, and right common iliac regions. An excisional lymph node biopsy was performed. Pathologic evaluation demonstrated follicular center site which stained positive for PAX5, CD20, CD10, Bcl-2, Bcl-6, and mantle zone cells. These findings demonstrated CCND1 and CD5 positivity, suggesting composite lymphoma comprising follicular lymphoma (FL) with in situ mantle cell lymphoma (MCLIS). FL is known as indolent non-Hodgkin lymphoma; however, the clinical significance of a coexisting MCLIS continues to be elusive, and optimal management of these patients remains largely unknown. This case illustrates the diagnostic and therapeutic challenges of composite lymphomas. This paper also discusses advances in molecular pathogenesis and lymphoma genomics which offer novel insights into these rare diseases.
Authors:
Josephine Taverna; Anju Nair; Seongseok Yun; Spencer Paulson; Jonathan H Schatz; Daniel Persky; Deborah Fuchs; Soham Puvvada
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-16
Journal Detail:
Title:  Case reports in hematology     Volume:  2014     ISSN:  2090-6560     ISO Abbreviation:  Case Rep Hematol     Publication Date:  2014  
Date Detail:
Created Date:  2014-12-5     Completed Date:  -     Revised Date:  2014-12-6    
Medline Journal Info:
Nlm Unique ID:  101576456     Medline TA:  Case Rep Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  145129     Citation Subset:  -    
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