Document Detail

A rare hematological manifestation of brucellosis: reactive hemophagocytic syndrome.
MedLine Citation:
PMID:  20457434     Owner:  NLM     Status:  MEDLINE    
Hemophagocytic syndrome (HS) may be primary, or secondary, to malignancy, or to metabolic, collagen vascular, and infectious diseases such as brucellosis, miliary tuberculosis and some viral and fungal infections. The diagnostic findings of HS are high fever, hepatosplenomegaly, cytopenia, high serum ferritin and triglycerides, and low serum fibrinogen levels. Brucellosis is a zoonotic disease, with fever, fatigue, sweating, arthritis, hepatosplenomegaly, lymphadenopathy, and cytopenia being the most common symptoms and findings. Hematological manifestations of the disease may include anemia, leucopenia, leukocytosis, thrombocytopenia, and thrombocytosis. Brucellosis may occur in association with HS. Here, we describe brucellosis associated HS in an 8 year-old male patient. The patient was admitted to our clinic with weight loss, arthralgia, prolonged fever, sweating, and fatigue. Physical and laboratory findings revealed hepatosplenomegaly, pancytopenia, elevated serum transaminases, triglycerides, lactate dehydrogenase, and ferritin, and with erythrocytes, leukocytes, and thrombocytes phagocytosed by macrophages indicating hemophagocytosis. The Brucella agglutination test was positive. The patient improved after treatment with Rifampin (15 mg/kg/day) and trimethoprim-sulfamethoxazole (10 mg/kg/day).
Erol Erduran; Melike Makuloglu; Mehmet Mutlu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi     Volume:  43     ISSN:  1995-9133     ISO Abbreviation:  J Microbiol Immunol Infect     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956211     Medline TA:  J Microbiol Immunol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Taiwan Society of Microbiology. Published by Elsevier B.V. All rights reserved.
Department of Pediatric Hematology, Karadeniz Technical University, Trabzon-Turkey.
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MeSH Terms
Agglutination Tests
Anti-Bacterial Agents / administration & dosage
Bacteriological Techniques
Bone Marrow / pathology
Brucella / immunology,  isolation & purification*
Brucellosis / complications*,  drug therapy,  pathology
Lymphohistiocytosis, Hemophagocytic / diagnosis*,  pathology
Rifampin / administration & dosage
Trimethoprim-Sulfamethoxazole Combination / administration & dosage
Reg. No./Substance:
0/Anti-Bacterial Agents; 13292-46-1/Rifampin; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

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