| A rare hematological manifestation of brucellosis: reactive hemophagocytic syndrome. | |
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MedLine Citation:
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PMID: 20457434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemophagocytic syndrome (HS) may be primary, or secondary, to malignancy, or to metabolic, collagen vascular, and infectious diseases such as brucellosis, miliary tuberculosis and some viral and fungal infections. The diagnostic findings of HS are high fever, hepatosplenomegaly, cytopenia, high serum ferritin and triglycerides, and low serum fibrinogen levels. Brucellosis is a zoonotic disease, with fever, fatigue, sweating, arthritis, hepatosplenomegaly, lymphadenopathy, and cytopenia being the most common symptoms and findings. Hematological manifestations of the disease may include anemia, leucopenia, leukocytosis, thrombocytopenia, and thrombocytosis. Brucellosis may occur in association with HS. Here, we describe brucellosis associated HS in an 8 year-old male patient. The patient was admitted to our clinic with weight loss, arthralgia, prolonged fever, sweating, and fatigue. Physical and laboratory findings revealed hepatosplenomegaly, pancytopenia, elevated serum transaminases, triglycerides, lactate dehydrogenase, and ferritin, and with erythrocytes, leukocytes, and thrombocytes phagocytosed by macrophages indicating hemophagocytosis. The Brucella agglutination test was positive. The patient improved after treatment with Rifampin (15 mg/kg/day) and trimethoprim-sulfamethoxazole (10 mg/kg/day). |
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Authors:
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Erol Erduran; Melike Makuloglu; Mehmet Mutlu |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi Volume: 43 ISSN: 1995-9133 ISO Abbreviation: J Microbiol Immunol Infect Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2010-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956211 Medline TA: J Microbiol Immunol Infect Country: England |
Other Details:
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Languages: eng Pagination: 159-62 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Taiwan Society of Microbiology. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatric Hematology, Karadeniz Technical University, Trabzon-Turkey. erolerduran@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Agglutination Tests Anti-Bacterial Agents / administration & dosage Bacteriological Techniques Bone Marrow / pathology Brucella / immunology, isolation & purification* Brucellosis / complications*, drug therapy, pathology Child Humans Lymphohistiocytosis, Hemophagocytic / diagnosis*, pathology Male Rifampin / administration & dosage Trimethoprim-Sulfamethoxazole Combination / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 13292-46-1/Rifampin; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination |
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