Document Detail


A Rare Case of Propofol-Induced Acute Liver Failure and Literature Review.
MedLine Citation:
PMID:  21103229     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The incidence of drug-induced acute liver failure is increasing. A number of drugs can inhibit mitochondrial functions, alter β-oxidation and cause accumulation of free fatty acids within the hepatocytes. This may result in hepatic steatosis, cell death and liver injury. In our case, propofol, an anesthetic drug commonly used in adults and children, is suspected to have induced disturbance of the mitochondrial respiratory chain, which in consequence led to insufficient energy supply and finally liver failure. We report the case of a 35-year-old Caucasian woman with acute liver failure after anesthesia for stripping of varicose veins. Liver histology, imaging and laboratory data indicate drug-induced acute liver failure, presumably due to propofol. Hepatocyte death and microvesicular fatty degeneration of 90% of the liver parenchyma were observed before treatment with steroids. Six months later, a second biopsy was performed, which revealed only minimal steatosis and minimal periportal hepatitis. We suggest that propofol led to impaired fatty acid oxidation possibly due to a genetic susceptibility. This caused free fatty acid accumulation within hepatocytes, which presented as hepatocellular fatty degeneration and cell death. Large scale hepatocyte death was followed by impaired liver function and, consecutively, progressed to acute liver failure.
Authors:
G Kneiseler; H S Bachmann; L P Bechmann; A Dechene; T Heyer; H Baba; F Saner; C Jochum; G Gerken; A Canbay
Related Documents :
20494149 - Effects of the peroxisome proliferator-activated receptor-alpha agonists clofibrate and...
6036539 - Difference in hepatic metabolism of long- and medium-chain fatty acids: the role of fat...
8215239 - Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachl...
22062569 - Effects of total iron, myoglobin, hemoglobin, and lipid oxidation of uncooked muscles o...
7409749 - Regulation of net triacylglycerol synthesis by metabolic substrates in isolated rat liv...
22908129 - Facile synthesis of 2-pyrazolines and α,β-diamino ketones via regioselective ring-ope...
17007439 - The use of hydroxyl-radical-generating systems for the treatment of olive mill wastewat...
6156749 - Composition of methanospirillum hungatii gp1 during growth on different media.
2358449 - Export of mitochondrially synthesized lysophosphatidic acid.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-2-06
Journal Detail:
Title:  Case reports in gastroenterology     Volume:  4     ISSN:  1662-0631     ISO Abbreviation:  -     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474819     Medline TA:  Case Rep Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  57-65     Citation Subset:  -    
Affiliation:
Division of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A Case of Neuroendocrine Malignant Tumor with Capsule Retention Diagnosed by Double-Balloon Enterosc...
Next Document:  The Association of Ménétrier Disease with Ulcerative Colitis: A Case Report with Implications on t...