Document Detail


Rapidly upsloping ST-segment on exercise ECG: a marker of reduced coronary heart disease mortality risk.
MedLine Citation:
PMID:  22492865     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: The prognostic value of an isolated J-point depression, or rapidly upsloping ST-segment, on an exercise ECG has long been assumed to be a benign variant. However, little or no data supporting this assumption may be found in the literature. Our task was to examine if a rapidly upsloping ST-segment on an exercise ECG is associated with changes in risk of dying from CHD in 2014 healthy middle-aged men followed for 35 years.Methods: A group of healthy middle-aged men (n = 2014) participated in a cardiovascular survey. They underwent an examination programme including a symptom-limited ECG bicycle exercise test. Exercise induced ST-segments were categorised in three groups: normal ST-segment (n = 1383), rapidly upsloping (n = 401), and ST-depression (n = 230). Survival analyses were adjusted for smoking status, total cholesterol, systolic blood pressure, maximal heart rate, and physical fitness. The mean follow-up time was 35 years.Results: The rapidly upsloping group had a 30% decreased risk of CHD death (hazard ratio, HR, 0.70, 95% CI 0.51-0.95) compared to the normal ST-segment group. The risk of CVD-death was numerically lower in the rapidly upsloping group (HR 0.82, 95% CI 0.65-1.04) compared to the normal ST-segment group. The ST-depression group had a 1.45-fold (HR 1.45, 95% CI 1.09-1.90) increased risk of CHD death compared to the normal ST-segment group.Conclusions: The rapidly upsloping ST-segment was a common finding (20%) on exercise ECG among healthy middle-aged men and was associated with a 30% reduced risk of dying from CHD compared to individuals with normal ST-segment. A rapidly upsloping ST-segment on exercise ECG may represent the true healthy state.
Authors:
Christian Hodnesdal; Erik Prestgaard; Gunnar Erikssen; Knut Gjesdal; Sverre E Kjeldsen; Knut Liestol; Per Torger Skretteberg; Jan Erikssen; Johan Bodegard
Related Documents :
1187275 - Exercise-induced asthma in children with intrinsic and extrinsic asthma.
7722165 - Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation.
7162705 - Autoradiographic patterns of hippocampal metabolism during induced hypothermia.
6467555 - Late response in exercise-induced asthma.
23660065 - Current flexor and extensor tendon motion regimens: a summary.
23715255 - Selected problems of medical qualification for physical fitness in postmenopausal women.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  European journal of preventive cardiology     Volume:  -     ISSN:  2047-4881     ISO Abbreviation:  Eur J Prev Cardiolog     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101564430     Medline TA:  Eur J Prev Cardiolog     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Oslo, Oslo, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tai Chi, arterial compliance, and muscle strength in older adults.
Next Document:  Chronotropic incompetence predicts impaired response to exercise training in heart failure patients ...