| Rapidly progressive Epstein-Barr virus-associated lymphoproliferative disorder unpredictable by weekly viral load monitoring. | |
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MedLine Citation:
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PMID: 20467179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD) following unrelated bone marrow transplantation (UBMT) for severe aplastic anemia treated with a conditioning regimen that included anti-thymocyte globulin (ATG). The patient showed signs of EBV reactivation as early as 34 days after UBMT. Our weekly schedule for EBV monitoring failed to trace rapid changes in EBV viral load and the patient eventually developed EBV-LPD. However, early intervention with monoclonal antibody against CD20, rituximab, stopped the further progression of EBV-LPD. As several recent reports have suggested, the safety and efficacy of rituximab treatment for EBV-LPD is supported by our limited experience with post transplant EBV-LPD. |
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Authors:
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Shihoko Wakabayashi; Kazuteru Ohashi; Ryo Hanajiri; Takeshi Kobayashi; Takuya Yamashita; Hideki Akiyama; Hisashi Sakamaki |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-05-14 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 931-5 Citation Subset: IM |
Affiliation:
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Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Aplastic
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therapy Antibodies, Monoclonal / therapeutic use Antilymphocyte Serum / adverse effects Bone Marrow Transplantation / adverse effects DNA, Viral / blood Disease Progression Epstein-Barr Virus Infections / etiology, therapy, virology* Herpesvirus 4, Human / isolation & purification Humans Lymphoproliferative Disorders / etiology, therapy, virology* Male Time Factors Transplantation Conditioning / adverse effects Transplantation, Homologous Viral Load* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antilymphocyte Serum; 0/DNA, Viral; 0/rituximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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