Document Detail

Rapidly evolving hepatitis C virus-related cirrhosis in a human immunodeficiency virus-infected patient receiving triple antiretroviral therapy.
MedLine Citation:
PMID:  9827279     Owner:  NLM     Status:  MEDLINE    
Triple antiretroviral therapy combining reverse transcriptase and protease inhibitors modifies the prognosis of human immunodeficiency virus (HIV) infection, with dramatic improvement in immune status. The precise impact, if any, of anti-HIV triple therapy on hepatitis C virus (HCV) infection is unknown. We describe an unusual case of rapidly evolving HCV-related cirrhosis that paralleled restoration of immune status in an HIV-infected patient and discuss the possible link between such a severe course of hepatitis C and anti-HIV triple therapy.
H Zylberberg; G Pialoux; F Carnot; A Landau; C Bréchot; S Pol
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  27     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-10     Completed Date:  1999-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1255-8     Citation Subset:  IM; X    
Unité d'Hépatologie, Hôpital Necker, Paris, France.
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MeSH Terms
Anti-HIV Agents / adverse effects*,  therapeutic use
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes / immunology
Drug Therapy, Combination
HIV Infections / complications*,  drug therapy*,  immunology
HIV Protease Inhibitors / adverse effects,  therapeutic use
Hepatitis C / complications*,  drug therapy,  virology
Indinavir / adverse effects,  therapeutic use
Lamivudine / adverse effects,  therapeutic use
Liver Cirrhosis / complications*,  pathology,  virology
Reverse Transcriptase Inhibitors / adverse effects,  therapeutic use
Stavudine / adverse effects,  therapeutic use
Reg. No./Substance:
0/Anti-HIV Agents; 0/HIV Protease Inhibitors; 0/Reverse Transcriptase Inhibitors; 134678-17-4/Lamivudine; 150378-17-9/Indinavir; 3056-17-5/Stavudine

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