Document Detail

Rapidly-adapting receptor activity and intratracheal pressure in guinea pigs. I. Action of leukotriene C4.
MedLine Citation:
PMID:  6597447     Owner:  NLM     Status:  MEDLINE    
Leukotriene C4 (LTC4) is a major component of slow-reacting substance of anaphylaxis (SRS-A) and is a potent bronchoconstrictor. In humans LTC4 results in bouts of coughing which suggests stimulation of pulmonary receptors involved in a reflex mechanism. Furthermore, atropine reduces the effect of both LTC4 and SRS-A. To test the hypothesis that LTC4 stimulates the rapidly-adapting or "irritant" receptor (RAR) of the airways, we administered LTC4 by both intravenous injection (10-1000 ng) and by aerosol delivery (1 microgram/ml) to the lungs of guinea pigs while recording arterial blood pressure, intratracheal pressure, and nerve activity from RARs. LTC4 (i.v.) concurrently increased both nerve activity and intratracheal pressure even at low doses in a dose-dependent manner. Therefore, a direct action of LTC4 (i.v.) upon the RAR is difficult to conclude. The separation of peak tracheal pressure and peak nerve activity was apparent with aerosol delivery of LTC4. The pattern of RAR activity during LTC4 aerosol challenge was unrelated to respiratory phase. FPL 55712 blocks the effects of SRS-A. We challenged the lung with 500 ng LTC4 intravenously before and after FPL 55712 injection (2.5 mg/kg). FPL 55712 blocked the increases of both tracheal pressure and RAR activity.
D R Bergren; D L Myers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and medicine     Volume:  16     ISSN:  0262-1746     ISO Abbreviation:  Prostaglandins Leukot Med     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-03-27     Completed Date:  1985-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206868     Medline TA:  Prostaglandins Leukot Med     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  147-61     Citation Subset:  IM; S    
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MeSH Terms
Blood Pressure / drug effects*
Chromones / pharmacology
Dose-Response Relationship, Drug
Guinea Pigs
Mechanoreceptors / physiology*
Muscle, Smooth / drug effects,  innervation,  physiology*
Pulmonary Stretch Receptors / drug effects,  physiology*
SRS-A / administration & dosage,  antagonists & inhibitors,  pharmacology*
Trachea / drug effects,  innervation,  physiology
Reg. No./Substance:
0/Aerosols; 0/Chromones; 0/SRS-A; 40786-08-1/FPL 55712

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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