Document Detail


Rapid virological response as a predictor of sustained response in HCV-infected patients with persistently normal alanine aminotransferase levels: A multicenter study.
MedLine Citation:
PMID:  20546499     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Rapid virological response (RVR) is now considered the strongest predictor of sustained virological response (SVR) in patients with HCV undergoing antiviral treatment, and thus, shorter antiviral treatment for these patients has been suggested. However, no data exist on the predictive value of RVR in HCV carriers with normal ALT values. A total of 137 patients with persistently normal ALT treated with peginterferon alfa 2a and ribavirin were studied. Fifteen patients dropped out early because of side effects, and in 10 patients with HCV-1 treatment was discontinued because of lack of early virological response (EVR). RVR was observed in 68% of the patients (42% patients with HCV-1, 90% HCV-2 and 64% HCV-3). An end-of-treatment response was observed in 86% of the patients (68% HCV-1, 100% HCV-2 and 91% HCV-3). SVR was maintained in 91 patients (46% HCV-1, 97% HCV-2 and 82% HCV-3). Overall, 92% patients with rapid response did obtain HCV eradication vs only 38% of those without rapid response. HCV-1 patients with baseline HCV RNA <400×10(3) IU/mL were more likely to achieve RVR and SVR than those with higher HCV RNA levels. We conclude that patients with genotype 1 and normal ALT who achieve HCV RNA negativity at week 4 may have a higher probability of eradicating their infection. Because of the concomitant favourable demographic and virological features often found in this particular subset of patients, the duration of therapy in these people might be shortened in the case of RVR. Persistently normal alanine aminotransferase levels patients with genotype 2 or 3 have a high chance of achieving SVR, so retesting of HCV RNA during treatment may have no additional practical value in these subjects.
Authors:
C Puoti; G Barbarini; A Picardi; M Romano; A Pellicelli; A Barlattani; F Mecenate; R Guarisco; O M Costanza; L Spilabotti; L Bellis; M E Bonaventura; O Dell' Unto; M G Elmo; A M Nicolini; L Nosotti; F Soccorsi;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of viral hepatitis     Volume:  18     ISSN:  1365-2893     ISO Abbreviation:  J. Viral Hepat.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-04-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435672     Medline TA:  J Viral Hepat     Country:  England    
Other Details:
Languages:  eng     Pagination:  393-9     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Department of Internal Medicine and Liver Unit, Marino Hospital, Rome, Italy. puoti@epatologia.org
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MeSH Terms
Descriptor/Qualifier:
Investigator
Investigator/Affiliation:
Daphné Bavoillot / ; Alessandro Braccioni / ; Chiara Dell'Unto / ; Laura Durola / ; Alessandra Galossi / ; Emanuela Conti / ; Renata Felici / ; Amerigo Paffetti / ; Ettore Mazzoni / ; Roberto Villani /

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