Document Detail

Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: effects on oxygenation, blood pressure and surfactant distribution.
MedLine Citation:
PMID:  8713657     Owner:  NLM     Status:  MEDLINE    
Surfactant bolus instillation may be associated with a drop in blood pressure. Platelet-activating factor (PAF) has been found in surfactant preparations. The aim of this study was to evaluate rapid tracheal infusion of surfactant during 5 min as an alternative to bolus instillation and to examine whether a PAF receptor antagonist is able to prevent the decrease in blood pressure. METHODS: Surfactant deficiency was induced in 16 adult rabbits by lung lavages with saline. Six animals received a bolus of a porcine surfactant preparation (Curosurf (CS); 200 mg/kg), labeled with red microspheres to assess pulmonary distribution. In another 5 rabbits, the same amount of labelled CS was instilled by tracheal infusion within 5 min. A third group of 5 animals received 3 mg/kg body weight of the PAF antagonist WEB 2170 before CS bolus instillation. RESULTS: After CS bolus administration, mean PaO2 increased by 44.7 +/- 8.3 kPa (mean +/- SD) within 2 min and remained at this level. Mean arterial blood pressure dropped transiently by 2.3 +/- 2 kPa within 5 min. Pulmonary distribution of surfactant was even. After infusion, mean PaO2 rose by 22.4 +/- 16.3 kPa within 15 min. Blood pressure dropped by 1.8 +/- 1.1 kPa within 15 min. The distribution was extremely uneven. Blood pressure decreases also occurred after pretreatment with PAF receptor antagonist. CONCLUSION: Rapid tracheal infusion of surfactant results in poorer oxygenation, an inhomogeneous distribution and a similar decrease in blood pressure compared to the bolus instillation method. Blood pressure changes could not be prevented by a PAF receptor-specific antagonist.
H Segerer; A Scheid; M H Wagner; M Lekka; M Obladen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  69     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1996  
Date Detail:
Created Date:  1996-09-19     Completed Date:  1996-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Department of Neonatology, Virchow Children's Hospital, Humboldt University, Berlin, Germany.
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MeSH Terms
Azepines / pharmacology
Blood Pressure / drug effects*
Lung / metabolism
Oxygen / blood*
Platelet Activating Factor / administration & dosage*,  metabolism,  pharmacology
Platelet Aggregation Inhibitors / pharmacology
Surface-Active Agents / administration & dosage*,  pharmacology
Tissue Distribution
Triazoles / pharmacology
Reg. No./Substance:
0/Azepines; 0/Platelet Activating Factor; 0/Platelet Aggregation Inhibitors; 0/Surface-Active Agents; 0/Triazoles; 114776-28-2/bepafant; 7782-44-7/Oxygen

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