Document Detail


Rapid thrombolysis and preservation of valvular venous function in high deep vein thrombosis. A comparative study between streptokinase and heparin therapy.
MedLine Citation:
PMID:  433668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The results of streptokinase and heparin treatment are compared in a 4-year prospective study with special reference to preservation of high valvular venous function. An objective assessment was based upon phlebographic examinations before, during and 1-2 months after therapy. Complete lysis was demonstrated in 44% of high thromboses treated with streptokinase and in 6% treated with heparin. Retrograde phlebography revealed normal function of the proximal femoral valves in 92% of streptokinase-treated high thromboses, compared with 13% of those treated with heparin. These phlebographic results were considered to be a valid prognostic indicator of the eventual development of the postthrombotic syndrome. Allergic reactions were seen in 39% and minor haemorrhagic complications in 18% of the streptokinase-treated cases. The therapeutic benefit of streptokinase therapy in this study was found to outweigh any disadvantages incurred by observed complications.
Authors:
R Watz; G F Savidge
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  205     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1979  
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  293-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Drug Evaluation
Female
Femoral Vein* / physiopathology
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / analysis
Heparin / administration & dosage,  adverse effects,  therapeutic use*
Humans
Iliac Vein* / physiopathology
Male
Middle Aged
Plethysmography
Prospective Studies
Streptokinase / administration & dosage,  adverse effects,  therapeutic use*
Thrombophlebitis / drug therapy*,  physiopathology
Time Factors
Venous Insufficiency / etiology,  prevention & control
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 9001-32-5/Fibrinogen; 9005-49-6/Heparin; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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